Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXRα Signaling in THP-1 Macrophage-Derived Foam Cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lin, Xiao-long*;Liu, Mi-Hua;Hu, Hui-Jun;Feng, Hong-ru;Fan, Xiao-Juan;...

通讯作者：

Lin, Xiao-long

作者机构：

[Hu, Hui-Jun; Zou, Wei-wen; Hu, Xue-mei; Lin, Xiao-long; Pan, Yong-quan; Fan, Xiao-Juan] Guangzhou Med Univ Huizhou City, Peoples Hosp Huizhou 3, Affiliated Hui Zhou Hosp, Dept Pathol, Huizhou 516002, Peoples R China.

[Lin, Xiao-long; Wang, Zuo] Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Hunan Prov, Hengyang, Peoples R China.

[Liu, Mi-Hua] Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang, Peoples R China.

[Feng, Hong-ru] Hebei Med Univ, Affiliated Hosp 1, Dept Ultrason Diag, Shijiazhuang, Peoples R China.

通讯机构：

[Lin, Xiao-long] G

Guangzhou Med Univ Huizhou City, Peoples Hosp Huizhou 3, Affiliated Hui Zhou Hosp, Dept Pathol, Huizhou 516002, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Curcuma longa;Protein kinase

期刊：

DNA AND CELL BIOLOGY

ISSN：

1044-5498

年：

2015

卷：

期：

页码：

561-572

DOI：

10.1089/dna.2015.2866

基金类别：

Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]; Visiting Scholar Foundation of Key Laboratory for Biorheological Science, Technology (Chongqing University) of Ministry of Education; medical foundation of Hui Zhou [2014Y149]; Medical Research Foundation of Guangdong Province [A2014810]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Curcumin, a traditional Chinese derivative from the rhizomes of Curcuma longa, is beneficial to health by modulating lipid metabolism and suppressing atherogenesis. A key part of atherosclerosis is the failure of macrophages to restore their cellular cholesterol homeostasis and the formation of foam cells. In this study, results showed that curcumin dramatically increased the expression of ATP-binding cassette transporter 1 (ABCA1), promoted cholesterol efflux from THP-1 macrophage-derived foam cells, and reduced cellular cholesterol levels. Cu...

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Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXRα Signaling in THP-1 Macrophage-Derived Foam Cells

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