Identification of the proteins related to p53-mediated radioresponse in nasopharyngeal carcinoma by proteomic analysis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zeng, Gu-Qing;Yi, Hong;Li, Xin-Hui;Shi, Hui-Ying;Li, Cui;...

通讯作者：

Xiao, Zhi-Qiang

作者机构：

[Qu, Jia-Quan; Li, Cui; Xiao, Zhi-Qiang; Wan, Xun-Xun; Xu, Yan; Feng, Xue-Ping; Yi, Hong; Li, Mao-Yu; Li, Xin-Hui; Zhang, Peng-Fei; Zeng, Gu-Qing; Shi, Hui-Ying; Sun, Yi; Chen, Zhu-Chu] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha 410008, Hunan, Peoples R China.

[Zeng, Gu-Qing] Univ S China, Sch Med, Dept Gen Surg & Operat Surg, Hengyang 421001, Peoples R China.

[Xiao, Zhi-Qiang] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Xiao, Zhi-Qiang] C

Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Nasopharyngeal carcinoma;P53;Proteomics;Radiobiology;Radiotherapy

期刊：

Journal of Proteomics

ISSN：

1874-3919

年：

2011

卷：

期：

页码：

2723-2733

DOI：

10.1016/j.jprot.2011.02.012

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973290]; Ministry of Education of ChinaMinistry of Education, China [2002-48]; Lotus Scholars Program of Hunan Province, China [2007-362]; Science and Technology Committee of Hunan, China [2010FJ2009]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Radiotherapy is the primary treatment for nasopharyngeal cancer (NPC), and p53 is closely associated with the radiosensitivity of cancer, but the molecular mechanisms of p53-mediated radioresponse in NPC remains unclear. We previously established NPC CNE2sip53 cell line with p53 knockdown and paired control cell line CNE2/pSUPER, which provides a cell model system to investigate mechanisms of p53-mediated radioresponse in NPC. In this study, we first compared the radiosensitivity of CNE2sip53 and CNE2/pSUPER by a clonogenic survival assay, cell growth assay, and Hoechst 33258 staining and flow...

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Identification of the proteins related to p53-mediated radioresponse in nasopharyngeal carcinoma by proteomic analysis

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