Role of microRNA in the Pathogenesis of Polycystic Ovary Syndrome

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Zhuo;Ou, Hanxiao;Wu, Hongliang;Wu, Peng*;Mo, Zhongcheng*

通讯作者：

Wu, Peng;Mo, Zhongcheng

作者机构：

[Wu, Hongliang; Ou, Hanxiao; Chen, Zhuo; Wu, Peng; Mo, Zhongcheng] Univ South China, Hunan Prov Innovat Training Base Med Postgrad, YueYang Maternal Child Med Hlth Hosp, Yueyang 414000, Hunan, Peoples R China.

[Wu, Hongliang; Ou, Hanxiao; Chen, Zhuo; Wu, Peng; Mo, Zhongcheng] Yueyang Women & Childrens Med Ctr, Yueyang 414000, Hunan, Peoples R China.

[Ou, Hanxiao; Mo, Zhongcheng] Univ South China, Hengyang Med Sch, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang, Hunan, Peoples R China.

[Mo, Zhongcheng] Univ South China, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wu, Peng; Mo, Zhongcheng] U

[Wu, Peng] Y

Univ South China, Hunan Prov Innovat Training Base Med Postgrad, YueYang Maternal Child Med Hlth Hosp, Yueyang 414000, Hunan, Peoples R China.

Yueyang Women & Childrens Med Ctr, Yueyang 414000, Hunan, Peoples R China.

Univ South China, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

follicular development;hyperandrogenism;insulin resistance;lipid metabolism;microRNA;polycystic ovary syndrome

期刊：

DNA AND CELL BIOLOGY

ISSN：

1044-5498

年：

2019

卷：

期：

页码：

754-762

DOI：

10.1089/dna.2019.4622

基金类别：

Horizontal cooperation project [2018KHX41]; Natural Sciences Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ40248, 2018JJ2344]; Scientific Research Innovation Program of postgraduate in Hu-nan Province [CX2018B623]; Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City [2017KJ182]; Chuanshan Talents Project in University of South China

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Polycystic ovary syndrome (PCOS) is the most typical metabolic syndrome in women of reproductive age, with a high prevalence and an increased risk of long-term complications. PCOS mainly manifests as hyperandrogenism (HA), ovulatory dysfunction, and polycystic ovaries, in addition to being relevant to infertility, insulin resistance (IR), obesity, lipid abnormalities, and chronic low-grade inflammation. The etiology of this syndrome remains largely unknown. microRNAs (miRNAs), small, noncoding RNAs (nearly 22 nucleotides long), regulate gene expression at the posttranscriptional level. Abnorma...

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Role of microRNA in the Pathogenesis of Polycystic Ovary Syndrome

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