GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cui, Jian;Li, Guoqing;Yin, Jie;Li, Linwei;Tan, Yue;...

通讯作者：

Yi, Lan

作者机构：

[Tang, Jialu; Yin, Jie; Tan, Yue; Yi, Lan; Liu, Bang; Chen, Yonglin; Cui, Jian; Li, Guoqing; Deng, Lihong; Wei, Haoran] Univ South China, Hengyang Med Coll, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Dept Educ,Inst Cytol & Genet, 28 Chang Sheng West Rd, Hengyang 421001, Hunan, Peoples R China.

[Yin, Jie; Yi, Lan; Li, Guoqing] Univ South China, Affiliated Hosp 2, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Li, Linwei] Univ South China, Affiliated Hosp 2, Dept Lab, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yi, Lan] U

Univ South China, Hengyang Med Coll, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Dept Educ,Inst Cytol & Genet, 28 Chang Sheng West Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Expression;Glutathione S-transferase Pi;Methylation;Polymorphism;Reactive oxygen species

期刊：

INTERNATIONAL JOURNAL OF ONCOLOGY

ISSN：

1019-6439

年：

2020

卷：

期：

页码：

867-878

DOI：

10.3892/ijo.2020.4979

基金类别：

Hunan Natural Science FoundationNatural Science Foundation of Hunan Province [2019JJ40238]; Defense Industrial Technology Development Program [JCKY2016403C001]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81400117]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014 M562115]; Research Initiation Funding of University of South China for the Returned Scholars From Abroad [2014XQD46]; Hunan Province University Students Study and Innovation Pilot Project [S201910555122]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Glutathione S-transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene that plays an important regulatory role in detoxification, anti-oxidative damage, and the occurrence of various diseases. The aim of the present study was to review the association between the expression of GSTP1 and the development and treatment of various cancers, and discuss GSTP1 methylation in several malignant tumors, such as prostate, breast and lung cancer, as well as hepatocellular carcinoma; to review the association between polymorphism of the GSTP1 gene an...

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GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)

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