Regulating the Warburg effect on metabolic stress and myocardial fibrosis remodeling and atrial intracardiac waveform activity induced by atrial fibrillation

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成果类型：

期刊论文

作者：

Hu, Heng-Jing;Zhang, Chi;Tang, Zhi-Han;Qu, Shun-Lin;Jiang, Zhi-Sheng*

通讯作者：

Jiang, Zhi-Sheng

作者机构：

[Jiang, Zhi-Sheng; Hu, Heng-Jing] Univ South China, Dept Cardiol Lab, Affiliated Hosp 1, Hengyang, Hunan, Peoples R China.

[Jiang, Zhi-Sheng; Tang, Zhi-Han; Qu, Shun-Lin; Zhang, Chi] Univ South China, Inst Cardiovasc Dis, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Zhi-Sheng; Tang, Zhi-Han; Qu, Shun-Lin; Zhang, Chi] Univ South China, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Zhi-Sheng; Hu, Heng-Jing] Univ South China, Postdoctoral Res Stn Basic Med, Hengyang, Hunan, Peoples R China.

通讯机构：

[Jiang, Zhi-Sheng] U

Univ South China, Inst Cardiovasc Dis, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atrial fibrillation;Pyruvate dehydrogenase kinase-1;Pyruvate dehydrogenase kinase-4;Warburg effect

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2019

卷：

516

期：

页码：

653-660

DOI：

10.1016/j.bbrc.2019.06.055

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81700306]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ3469]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M622588]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Atrial fibrillation (AF) is associated with metabolic stress and induces myocardial fibrosis reconstruction by increasing glycolysis. One goal in the treatment of paroxysmal AF (p-AF) is to improve myocardial fibrosis reconstruction and myocardial metabolic stress caused by the Warburg effect. Adopted male canine that rapid right atrial pacing (RAP) for 6 days to establish a p-AF model. The canines were pre-treated with phenylephrine (PE) or dichloroacetic acid (DCA) before exposure to p-AF or non-p-AF. P-wave duration (P-max), minimum P-wave duration (P-min), P wave dispersion (PWD), atrial e...

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Regulating the Warburg effect on metabolic stress and myocardial fibrosis remodeling and atrial intracardiac waveform activity induced by atrial fibrillation

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