期刊论文

Chen, Wei

英文

Gene

0378-1119

2020

726

144136

10.1016/j.gene.2019.144136

This study was supported by (1) Science and Health Joint Project of Natural Science Foundation in Hunan province (2018JJ6069), (2) Research Project of Health and Family Planning Commission in Hunan province (B20180057), (3) Youth Academic Leadership Project of the Second Affiliated Hospital of university of South China. Statement of ethics All the animal procedures were performed in accordance with institutional guidelines and approved by the Institute Research Ethics Committee of the Second Affiliated Hospital of University of South China.

本校为第一且通讯机构

Chronic systolic heart failure (CSHF) was a complex syndrome. Recently, vagus nerve stimulation (VNS), a novel treatment method, has emerged for the treatment of CSHF. therefore the aim of this study was to explore the possible mechanism of VNS treatment alleviating CSHF in rats. Firstly, we found after VNS treatment for 72 h, the level of B-type natriuretic peptide in VNS group was lower than that in CSHF group. In addition, VNS treatment induced the elevated left ventricular ejection fraction level, reduced left ventricular end diastolic volume and left ventricular end systolic volume level ...