Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators

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成果类型：

期刊论文

作者：

Tan, Tan;Wu, Chuanfen;Liu, Boye;Pan, Bih-Fang;Hawke, David H.;...

通讯作者：

Sue-Hwa Lin<&wdkj&>Jian Kuang

作者机构：

[Tan, Tan; Kuang, Jian; Wu, Chuanfen; Wang, Ruoning] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA.

[Pan, Bih-Fang; Hawke, David H.] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA.

[Lin, Sue-Hwa] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA.

[Tan, Tan] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Liu, Boye] Beijing Normal Univ, Coll Life Sci, Key Lab Biodivers & Ecol Engn, Minist Educ, Beijing 100875, Peoples R China.

语种：

英文

期刊：

MOLECULAR BIOLOGY OF THE CELL

ISSN：

1059-1524

年：

2022

卷：

期：

页码：

ar115

DOI：

10.1091/mbc.E22-04-0118

基金类别：

DOD/PCRP [W81XWH-09-1-0274]; NIH [CA174798, P50 CA140388, P30 CA016672, 1S10OD012304-01, P30CA016672]; CPRIT [RP150179, RP150282, RP130397]; Natural Science Foundation of Hunan province [2020JJ5478]; NIH/NCI [P30CA016672]

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

The term M-phase supershift denotes the phosphorylation-dependent substantial increase in the apparent molecular weight of numerous proteins of varied biological functions during M-phase induction. Although the M-phase supershift of multiple key mitotic regulators has been attributed to the multisite phosphorylation catalyzed by the Cdk1/cyclin B/Cks complex, this view is challenged by multiple lines of paradoxical observations. To solve this problem, we reconstituted the M-phase supershift of Xenopus Cdc25C, Myt1, Wee1A, APC3, and Greatwall in Xenopus egg extracts and characterized the supers...

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Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators

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