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Three polypeptides screened from phage display random peptide library may be the receptor polypeptide of Mycoplasma genitalium adhesion protein

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成果类型:
期刊论文
作者:
Deng, Xiangying;Zhu, Youcong;Dai, Pei;Yu, Minjun;Chen, Liesong;...
通讯作者:
Zeng, Yanhua
作者机构:
[Dai, Pei; Zhu, Youcong; Deng, Xiangying; Chen, Liesong; Zhu, Cuiming; Yu, Minjun; You, Xiaoxing; Zeng, Yanhua; Li, Lingling] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pathogen Biol,Med Coll, Hengyang 421001, Peoples R China.
通讯机构:
[Zeng, Yanhua] U
Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pathogen Biol,Med Coll, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Mycoplasma genitalium;MgPa;Receptor polypeptides;SV-HUC-1 cells
期刊:
Microbial Pathogenesis
ISSN:
0882-4010
年:
2018
卷:
120
页码:
140-146
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31370207]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Mycoplasma genitalium adhesion protein (MgPa) is a major adhesin of M. genitalium, a human pathogen associated with a series of genitourinary tract diseases. MgPa plays a very important role in M. genitalium adhering to the host cells. However, the exact receptor peptides or proteins of MgPa are still poorly understood so far. Three polypeptides (V-H-W-D-F-R-Q-W-W-Q-P-S), (D-W-S-S-W-V -Y-R-D-P-Q-T) and (H-Y-I-D-F-R-W) were previously screened from a phage display random peptide library using recombinant MgPa (rMgPa) as a target molecule. In this study, three polypeptides were artificially synt...

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