National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770454]; Natural Science Foundation of Hunan provinceNatural Science Foundation of Hunan Province [2018JJ2343]; Key Project of the Education Department of Hunan Province [18A241]; International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province [2018WK4031]; Research Project of the Health and Family Planning Commission of Hunan Province [B2016088]; Firstclass Discipline in Hunan Province [2018XJXZ366, 2018XJXZ369]; Undergraduate Innovative Experiment Project [2018XJXZ366, 2018XJXZ369]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Proprotein convertase subtilisin kexin 9 (PCSK9)regulates lipid metabolism by degrading low-density lipoprotein receptor on the surface of hepatocytes. PCSK9-mediated lipid degradation is associated with lipophagy. Lipophagy is a process by which autophagosomes selectively sequester lipid-droplet-stored lipids and are delivered to lysosomes for degradation. Lipophagy was first discovered in hepatocytes, and its occurrence provides important fundamental insights into how lipid metabolism regulates cellular physiology and pathophysiology. Further...
