lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling

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成果类型：

期刊论文

作者：

Lin, Xiaoting;Zhuang, Shiwen;Chen, Xue;Du, Jun;Zhong, Longhua;...

通讯作者：

Ye, Feng;Liu, Wen;Luo, Xi

作者机构：

[Ye, Feng; Lin, Xiaoting; Zhuang, Shiwen; Zhong, Longhua] Xiamen Univ, Dept Med Oncol, Xiamen Key Lab Antitumor Drug Transformat Res, Affiliated Hosp 1, Xiamen 361003, Peoples R China.

[Ye, Feng; Lin, Xiaoting; Zhuang, Shiwen] Fujian Med Univ, Dept Clin Med, Fuzhou 350122, Peoples R China.

[Ding, Jiancheng; Hu, Guosheng; Yi, Jia; Chen, Xue; Du, Jun; Wang, Lei; Liu, Wen] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361104, Peoples R China.

[Tang, Guohui] Univ South China, Affiliated Nanhua Hosp, Dept Anus & Bowels, Hengyang 421010, Peoples R China.

[Luo, Xi] Xiamen Univ, Affiliated Hosp 1, BE Phase Clin Ctr 1, Xiamen 361003, Peoples R China.

通讯机构：

[Ye, Feng] F

[Liu, Wen; Luo, Xi] X

Fujian Med Univ, Dept Clin Med, Fuzhou 350122, Peoples R China.

Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361104, Peoples R China.

Xiamen Univ, Affiliated Hosp 1, BE Phase Clin Ctr 1, Xiamen 361003, Peoples R China.

语种：

英文

关键词：

ITGA3;ITGB3;ITGB8-AS1;ceRNA;colorectal cancer;focal adhesion;integrin;lncRNA

期刊：

Molecular Therapy

ISSN：

1525-0016

年：

2022

卷：

期：

页码：

688-702

DOI：

10.1016/j.ymthe.2021.08.011

基金类别：

Natural Science Foundation of Fujian ProvinceNatural Science Foundation of Fujian Province [2020J05300]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82002496, 91953114, 81761128015, 81861130370, 31871319]; National Major Scientific and Technological Special Project for "Significant New Drugs Development" [2020ZX09201005]

机构署名：

本校为其他机构

摘要：

Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and progression of colorectal cancer (CRC). However, functions of most lncRNAs in CRC and their molecular mechanisms remain uncharacterized. Here we found that lncRNA ITGB8-AS1 was highly expressed in CRC. Knockdown of ITGB8-AS1 suppressed cell proliferation, colony formation, and tumor growth in CRC, suggesting oncogenic roles of ITGB8-AS1. Transcriptomic analysis followed by KEGG analysis revealed that focal adhesion signaling was the most significantly enriched pathway for g...

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lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling

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