Tissue factor pathway inhibitor in atherosclerosis

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成果类型：

期刊论文

作者：

Yuan, Hou-Qin;Hao, Ya-Meng;Ren, Zhong;Gu, Hong-Feng;Liu, Feng-Tao;...

通讯作者：

Jiang, Zhi-Sheng

作者机构：

[Jiang, Zhi-Sheng; Hao, Ya-Meng; Ren, Zhong; Tang, Zhi-Han; Qu, Shun-Lin; Yuan, Hou-Qin; Yan, Bin-Jie; Liu, Lu-Shan] Univ South China, Inst Cardiovasc Dis, Hengyang Med Coll, Key Lab Arteriosclerosis Hunan Prov, Hengyang City 421001, Hunan, Peoples R China.

[Gu, Hong-Feng] Univ South China, Dept Physiol, Hengyang Med Coll, Hengyang City 421001, Hunan, Peoples R China.

[Liu, Feng-Tao] Univ South China, Hengyang Med Coll, Ctr Funct Lab, Hengyang City 42100, Hunan, Peoples R China.

[Chen, Da-Xing] Kings Coll London, Guys Hosp, Fac Life Sci & Med, Div Transplantat Immunol & Mucosal Biol, London SE1 9RT, England.

通讯机构：

[Jiang, Zhi-Sheng] U

Univ South China, Inst Cardiovasc Dis, Hengyang Med Coll, Key Lab Arteriosclerosis Hunan Prov, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Tissue factor pathway inhibitor

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2019

卷：

491

页码：

97-102

DOI：

10.1016/j.cca.2019.01.024

基金类别：

The work was supported by the National Natural Science Foundation of China (81670429, 81470435 to ZS.Jiang), International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province (2018WK4031), Graduate Research and Innovation Project of Hunan Province (CX2018B586), “Double First-Class” project for innovative Group of Basic Medicine, University of South China (to ZS.Jiang).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Tissue factor pathway inhibitor (TFPI) reduces the development of atherosclerosis by regulating tissue factor (TF) mediated coagulation pathway. In this review, we focus on recent findings on the inhibitory effects of TFPI on endothelial cell activation, vascular smooth muscle cell (VSMC) proliferation and migration, inflammatory cell recruitment and extracellular matrix which are associated with the development of atherosclerosis. Meanwhile, we are also concerned about the impact of TFPI levels and genetic polymorphisms on clinical atherogenes...

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Tissue factor pathway inhibitor in atherosclerosis

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