This work is supported by the Natural Science Foundation of China (Grant No. 81272993), and Program of Science and Technology Bureau of Hengyang city (Grant No. 2015KJ17). Graduate Student Research Innovation Project of University of South China (Grant No. 2016XCX39). The experiments were performed at the South University of China. We thank the efforts that all the colleges contributed to this work.
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
公共卫生学院
摘要:
Deinococcus radiodurans has attracted a great interest in the past decades due to its extraordinary resistance to ionizing radiation and highly efficient DNA repair system. Recent studies indicated that pprM is a putative pleiotropic gene in D. radiodurans and plays an important role in radioresistance and antioxidation, but its underlying mechanisms are poorly elucidated. In this study, pprM mutation was generated to investigate resistance to desiccation and oxidative stress. The result showed that the survival of pprM mutant under desiccation...