FB-15 inhibits MGC-803 cells growth by regulating energy metabolism

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成果类型：

期刊论文

作者：

Deng, Xiangping;Pi, Yiyuan;Li, Zhongli;Xiong, Runde;Liu, Juan;...

通讯作者：

Lei, Xiaoyong;Tang, Guotao

作者机构：

[Deng, Xiangping; Xie, Zhizhong; Li, Zhongli; Liu, Juan; Lei, Xiaoyong; Pi, Yiyuan; Zhao, Jingduo; Tang, Guotao; Xiong, Runde] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang City, Hunan, Peoples R China.

[Deng, Xiangping; Xie, Zhizhong; Lei, Xiaoyong; Pi, Yiyuan; Zhao, Jingduo; Tang, Guotao] Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang City, Hunan, Peoples R China.

[Pi, Yiyuan] Xiangnan Univ, Chenzhou City, Hunan, Peoples R China.

[Lei, XY; Tang, Guotao] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Lei, XY; Tang, GT] U

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Antitumor;FB-15;HIF-1α;MGC-803;Tubulin

期刊：

Chemico-Biological Interactions

ISSN：

0009-2797

年：

2020

卷：

327

页码：

109186

DOI：

10.1016/j.cbi.2020.109186

基金类别：

CRediT authorship contribution statement Xiangping Deng: Data curation, Methodology, Project administration, Writing - original draft. Yiyuan Pi: Data curation, Investigation, Project administration. Zhongli Li: Methodology. Runde Xiong: Software. Juan Liu: Methodology. Jingduo Zhao: Software. Zhizhong Xie: Writing - review & editing. Xiaoyong Lei: Conceptualization, acquisition. Guotao Tang: Conceptualization, Project administration, Supervision, acquisition.

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

In this study, we scrutinized the anticancer effects of FB-15 on human gastric carcinoma MGC-803 cells in vitro and vivo, and its preliminary effect on tubulin and HIF-1α. We confirmed that FB-15 not only inhibited the proliferation of a large number of cells in a concentration and time-dependent manner but also inhibited proliferation of a single cell to form clones. FB-15 manifested little cytotoxicity for normal stomach cells GES-1. The flow cytometry analysis displayed that FB-15 induced apoptosis MGC-803 cells and mainly arrested cells in...

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FB-15 inhibits MGC-803 cells growth by regulating energy metabolism

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