Immune-related adverse events with PD-1/PD-L1 inhibitors: insights from a real-world cohort of 2523 patients

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yan, Ting;Long, Minghui;Liu, Chaoyi;Zhang, Jiwen;Wei, Xingyu;...

通讯作者：

Liao, DH

作者机构：

[Wei, Xingyu; Yan, Ting; Zhang, Jiwen; Liao, DH; Long, Minghui; Li, Fei; Liao, Dehua] Cent South Univ, Hunan Canc Hosp, Affiliated Canc Hosp, Xiangya Sch Med,Dept Pharm, Changsha, Peoples R China.

[Liu, Chaoyi] Cent South Univ, Hunan Canc Hosp, Affiliated Canc Hosp, Xiangya Sch Med,Dept Informat, Changsha, Peoples R China.

[Wei, Xingyu; Zhang, Jiwen; Li, Fei] Univ South China, Sch Pharm, Hengyang, Peoples R China.

通讯机构：

[Liao, DH ] C

Cent South Univ, Hunan Canc Hosp, Affiliated Canc Hosp, Xiangya Sch Med,Dept Pharm, Changsha, Peoples R China.

语种：

英文

关键词：

PD-1/PD-L1 inhibitors;efficacy;immune-related adverse events;real-world study;retrospective analysis;tumor therapy

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2025

卷：

页码：

1519082

DOI：

10.3389/fphar.2025.1519082

基金类别：

Hunan Provincial Natural Science Foundation of China [2024JJ8181, 2024JJ8206]; Climbing Plan of Hunan Cancer Hospital [2021NSFC-A003]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

PURPOSE: Immune checkpoint inhibitors (ICIs) have significantly changed cancer therapy, improving patient survival rates and clinical outcomes. Nevertheless, the use of PD-1/PD-L1 inhibitors can result in immune-related adverse events (irAEs). This study aims to investigate the prevalence and associated risk factors of irAEs in a real-world setting, as well as to assess their effects on optimal therapeutic outcomes. METHODS: A retrospective analysis involved 2523 patients with cancer who received inpatient PD-1/PD-L1 inhibitors treatment between January 2018 and December 2022. We documented pa...

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Immune-related adverse events with PD-1/PD-L1 inhibitors: insights from a real-world cohort of 2523 patients

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