Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats

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成果类型：

期刊论文

作者：

Lei, Xiaocan;Huo, Peng;Wang, Yaohui;Xie, Yuanjie;Shi, Qingxiang;...

通讯作者：

Mo, Zhongcheng;Zhang, Shun

作者机构：

[Lei, Xiaocan; Xie, Yuanjie; Mo, Zhongcheng] Univ South China, Dept Histol & Embryol, Clin Anat & Reprod Med Applicat Inst, Hengyang, Peoples R China.

[Huo, Peng] Guilin Med Univ, Sch Publ & Hlth, Guilin, Peoples R China.

[Shi, Qingxiang; Wang, Yaohui] Zunyi Med Univ, Sch Basic Med, Zunyi, Guizhou, Peoples R China.

[Yao, Jun; Zhang, Shun; Tu, Haoyan] Guilin Med Univ, Affiliated Hosp, Dept Reprod Med Ctr, Guilin, Peoples R China.

通讯机构：

[Mo, Zhongcheng] U

[Zhang, Shun] G

Univ South China, Dept Histol & Embryol, Clin Anat & Reprod Med Applicat Inst, Hengyang, Peoples R China.

Guilin Med Univ, Affiliated Hosp, Dept Reprod Med Ctr, Guilin, Peoples R China.

语种：

英文

关键词：

diabetes;HIF-1α;LBP;PCNA;SIRT1;testis

期刊：

FRONTIERS IN ENDOCRINOLOGY

ISSN：

1664-2392

年：

2020

卷：

页码：

518276

DOI：

10.3389/fendo.2020.00164

基金类别：

The present study was supported by the China National Natural Science Fund (Nos. 81860733 and 81960274), Guangxi Science Foundation (No. 2017GXNSFBA198189), the Science and Technology Fund of Guizhou Province (No. Qian Basic [2019]1344), National Innovation and Entrepreneurship Training Program for College Students (No. 201810661017 and zunyi201751022), and a Key Project of Guangxi Natural Science Foundation (No. 2018GXNSFDA050003).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

The objective of this study was to investigate the protective effects of Lycium barbarum polysaccharides (LBP) on testicular spermatogenic function in streptozotocin (STZ)-induced diabetic rats. Compared to the control group, blood glucose levels were significantly increased and the insulin resistance was markedly aggravated in STZ-induced diabetic rats. Further, the weight of testis and epididymis and the sperm number and motility were decreased in diabetic rats. Pathological changes were also observed in the spermatogenic tubules, along with ...

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Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats

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