Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway

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成果类型：

期刊论文

作者：

Liu, Haohao;Zeng, Xin;Ma, Ya;Chen, Xinghai;Losiewicz, Michael D.;...

通讯作者：

Yang, F.;Zhang, H.

作者机构：

[Ma, Ya; Zhang, Shiyu; Liu, Haohao; Zhang, Huizhen; Zeng, Xin; Du, Xingde; Tian, Zhihui; Shi, Linjia] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China.

[Chen, Xinghai; Losiewicz, Michael D.] St Marys Univ, Dept Chem & Biochem, San Antonio, TX USA.

[Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haz, Hengyang 421001, Hunan, Peoples R China.

[Yang, Fei] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Zhang, H.] C

[Yang, F.] H

College of Public Health, Henan, China

Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, Hunan, China

语种：

英文

关键词：

Microcystin-leucine arginine;BTB damages;Reproductive toxicity;Adherens junction changes;Cytoskeleton rearrangement;Water pollution

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2022

卷：

236

页码：

113454

DOI：

10.1016/j.ecoenv.2022.113454

基金类别：

The authors would like to acknowledge the financial support from the National Nature Science Foundation of China (Grant Nos. 82073512, 81773384 and 81773393 ), Key Research and Development Projects in Hunan Province (Grant No. 2022SK2089, 2019SK2041 ), Hunan Province Excellent Youth Fund ( 2020JJ3053 ).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Microcystin-leucine arginine (MC-LR), an emerging water pollutant, produced by cyanobacteria, has an acute testicular toxicity. However, little is known about the chronic toxic effects of MC-LR exposure on the testis at environmental concentrations and the underlying molecular mechanisms. In this study, C57BL/6 J mice were exposed to different low concentrations of MC-LR for 6, 9 and 12 months. The results showed that MC-LR could cause testis structure loss, cell abscission and blood-testis barrier (BTB) damage. Long-term exposure of MC-LR also...

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Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway

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