Targeting Acetyl-CoA Carboxylases: Small Molecular Inhibitors and their Therapeutic Potential

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Luo, Di-Xian;Tong, Di-Jun;Rajput, Sandeep;Wang, Chun;Liao, Duan-Fang;...

通讯作者：

Maser, Edmund

作者机构：

[Luo, Di-Xian] First Peoples Hosp Chenzhou, Inst Translat Med, Chenzhou 423000, Hunan, Peoples R China.

[Maser, Edmund] Univ Med Sch Schleswig Holstein, Inst Toxicol & Pharmacol Nat Scientists, D-24105 Kiel, Germany.

[Luo, Di-Xian] First Peoples Hosp Chenzhou, Dept Lab Med, Chenzhou 423000, Hunan, Peoples R China.

[Luo, Di-Xian; Rajput, Sandeep; Cao, Deliang] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA.

[Tong, Di-Jun] Cent Hosp Yiyang, Dept Cardiovasc Med, Yiyang 41300, Peoples R China.

通讯机构：

[Maser, Edmund] U

Univ Med Sch Schleswig Holstein, Inst Toxicol & Pharmacol Nat Scientists, Campus Kiel,Brunswiker Str 10, D-24105 Kiel, Germany.

语种：

英文

关键词：

Acetyl-CoA carboxylases;cancer;fatty acid synthesis;inhibitors;metabolic syndromes;obesity

期刊：

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY

ISSN：

1574-8928

年：

2012

卷：

期：

页码：

168-184

DOI：

10.2174/157489212799972918

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Acetyl-CoA carboxylases (ACCs) play a rate-limiting role in fatty acid biosynthesis in plants, microbes, mammals and humans. ACCs have the activity of both biotin carboxylase (BC) and carboxyltransferase (CT), catalyzing carboxylation of Acetyl-CoA to malonyl-CoA. In the past years, ACCs have been used as targets for herbicides in agriculture and for drug discovery and development of human diseases, such as microbial infections, diabetes, obesity and cancer. A great number of small molecule ACC inhibitors have been developed, including natural and non-natural (artificial) products. These chemi...

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