Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

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成果类型：

期刊论文

作者：

Liu, Yufeng;Cheng, Yuan;Zhang, He;Zhou, Min;Yu, Yijun;...

通讯作者：

Butch, Christopher J.;Wei, Hui

作者机构：

[Cheng, Yuan; Liu, Yufeng; Butch, Christopher J.; Wei, Hui; Butch, CJ; Wei, Chuan-Wan; Zhou, Min; Lin, Shichao] Nanjing Univ, Coll Engn & Appl Sci, Dept Biomed Engn, Nanjing 210093, Jiangsu, Peoples R China.

[Zhang, He] Nanjing Univ, Med Sch, Dept Periodontol, Nanjing Stomatol Hosp, Nanjing 210093, Jiangsu, Peoples R China.

[Miao, Leiying; Yu, Yijun] Nanjing Univ, Med Sch, Dept Cariol & Endodont, Nanjing Stomatol Hosp, Nanjing 210093, Jiangsu, Peoples R China.

[Jiang, Bo; Zhao, Xiaozhi] Nanjing Univ, Dept Urol, Drum Tower Hosp, Med Sch,Inst Urol, Nanjing 210008, Jiangsu, Peoples R China.

[Lin, Ying-Wu; Wei, Chuan-Wan] Univ South China, Sch Chem & Chem Engn, Lab Prot Struct & Funct, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Butch, CJ; Wei, H; Wei, Hui] N

Nanjing Univ, Coll Engn & Appl Sci, Dept Biomed Engn, Nanjing 210093, Jiangsu, Peoples R China.

Nanjing Univ, Nanjing Natl Lab Microstruct, Jiangsu Key Lab Artificial Funct Mat, Nanjing 210093, Jiangsu, Peoples R China.

Nanjing Univ, State Key Lab Analyt Chem Life Sci, Sch Chem & Chem Engn, Chem & Biomed Innovat Ctr ChemBIC, Nanjing 210023, Jiangsu, Peoples R China.

Nanjing Univ, State Key Lab Coordinat Chem, Sch Chem & Chem Engn, Chem & Biomed Innovat Ctr ChemBIC, Nanjing 210023, Jiangsu, Peoples R China.

语种：

英文

期刊：

Science Advances

ISSN：

2375-2548

年：

2020

卷：

期：

DOI：

10.1126/sciadv.abb2695

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21722503, 21874067]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20180340]; PAPD Program; Open Funds of the State Key Laboratory of Analytical Chemistry for Life Science [SKLACLS1704]; Open Funds of the State Key Laboratory of Coordination Chemistry [SKLCC1819]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [021314380145, 021414380485, YK2005002]

机构署名：

本校为其他机构

院系归属：

化学化工学院

摘要：

Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide dismutase by incorporation of a Mn-[5,10,15,20tetrakis(4-carboxyphenyl)porphyrinato]-based metal-organic framework compound capable of transforming oxygen radicals to hydrogen peroxide. The second mimicked functionality is that of catalase by incorporation of Pt nanoparticles, which catalyze hydrogen peroxide disproportionation to water and oxygen. Both in vitro and in vivo ex...

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Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

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