期刊论文

Li, Lanfang

英文

Clinica Chimica Acta

0009-8981

2016

456

81-88

10.1016/j.cca.2016.02.025

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270420, 81470434, 81470435, 81170277]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [14JJ3102]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014 M560647, 2015T80875]; Hunan Provincial Science and Technology Project [2015RS4040]; Administration of Traditional Chinese Medicine of Hunan Province [201,578]; Health and Family Planning Commission of Hunan Province [B2015-48]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department document) [2014-405]

本校为第一且通讯机构

Apelin, an endogenous ligand of the G-protein-coupled receptor APJ, is expressed in a diverse number of organs. The apelin-APJ axis helps to control the processes of pathological and physiological fibrosis, including renal fibrosis, cardiac fibrosis, liver fibrosis and pulmonary fibrosis. However, the role of apelin-APJ in organ fibrosis remains controversial due to conflicting study results. The apelin-APJ axis is a detrimental mechanism which promotes liver fibrosis mainly via up-regulation the expression of collagen-II and platelet-derived g...