SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals - 成果

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SARS-CoV-2 spike-specific T_FH cells exhibit unique responses in infected and vaccinated individuals

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

He, Rongzhang;Zheng, Xingyu;Zhang, Jian;Liu, Bo;Wang, Qijie;...

通讯作者：

Qu, XW;Li, YP;Wang, YC

作者机构：

[Zheng, Xingyu; Qu, Xiaowang; He, Rongzhang; Liu, Wenpei] Univ South China, Hengyang Med Sch, Coll Basic Med Sci, Hengyang 421001, Peoples R China.

[Zheng, Xingyu; Qu, Xiaowang; He, Rongzhang; Liu, Wenpei] MOE Key Lab Rare Pediat Dis, Hengyang 421001, Peoples R China.

[Zheng, Xingyu; Zhang, Jian; Wang, You; Pan, Dong; Liu, Ziyan; Liu, Bo; Lu, Rui; Chen, Jun; Wu, Qian; Qu, Xiaowang; Teng, Shishan; Peng, Liting; He, Rongzhang; Hu, Yabin; Yang, Jing; Liu, Wenpei] Univ South China, Translat Med Inst, Peoples Hosp Chenzhou 1, Chenzhou 423000, Peoples R China.

[Xie, Ting; Wang, Qijie] Cent Hosp Shaoyang, Shaoyang 422000, Peoples R China.

[Liu, Yongchen; Li, Yi-Ping; Chang, Fangfang; Wu, Qian; Li, YP] Sun Yat Sen Univ, Inst Human Virol, Zhongshan Sch Med, Guangzhou 501180, Peoples R China.

通讯机构：

[Qu, XW ] U

[Li, YP ] S

[Wang, YC ] N

Univ South China, Hengyang Med Sch, Coll Basic Med Sci, Hengyang 421001, Peoples R China.

MOE Key Lab Rare Pediat Dis, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

信号转导与靶向治疗

ISSN：

2095-9907

年：

2023

卷：

期：

页码：

393

DOI：

10.1038/s41392-023-01650-x

基金类别：

The authors thank all of the participants. This work was supported by the National Natural Science Foundation of China (92269115, 82061138020, 32270996, 82102365), The Science and Technology Innovation Program of Hunan Province of China (2022RC3079), Natur [92269115, 82061138020, 32270996, 82102365]; National Natural Science Foundation of China [2022RC3079]; Science and Technology Innovation Program of Hunan Province of China [2021JJ40006, 2022JJ30095]; Natural Science Foundation of Hunan Province of China [21A0529]; Educational Commission of Hunan Province of China [2021SK50304, 2021SK50306, 2021SK50312]; Clinical Medical Innovation Technology Guide Project of Hunan Province [B202303087545, D202302076189]; General Project of Health Commission of Hunan Province [101003562]; European Commission [KP-06-DK-3/2]; NSF; Republic of Bulgaria

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (T(FH)) cells. However, the longevity and functional role of T(FH) cell subsets in COVID-19 convalescents and vaccine recipients remain poorly defined. Here, we show that SARS-CoV-2 infection and inactivated vaccine elicited both spike-specific CXCR3(+) T(FH) cell and CXCR3(-) T(FH) cell responses, which showed distinct response patterns. Spike-specific CXCR3(+) T(FH) cells exhibit a dominant and mo...

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SARS-CoV-2 spike-specific T_FH cells exhibit unique responses in infected and vaccinated individuals

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