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Proteomics analysis of liver tissues from C57BL/6J mice receiving low-dose Cs-137 radiation

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成果类型:
期刊论文
作者:
Yi, Lan;Li, Linwei;Yin, Jie;Hu, Nan;Li, Guangyue;...
通讯作者:
Ding, Dexin
作者机构:
[Ding, Dexin; Yin, Jie; Yi, Lan; Li, Guangyue; Hu, Nan] Univ South China, Key Discipline Lab Natl Def Biotechnol Uranium Mi, Hengyang 421001, Hunan, Peoples R China.
[Yin, Jie; Yi, Lan; Li, Linwei] Univ South China, Coll Pharm & Biol Sci, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Ding, Dexin] U
Univ South China, Key Discipline Lab Natl Def Biotechnol Uranium Mi, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Low-dose irradiation;Proteomics;C57BL/6EJ mice;CAT;GNMT;GSTP1
期刊:
Environmental Science and Pollution Research
ISSN:
0944-1344
年:
2016
卷:
23
期:
3
页码:
2549-2556
基金类别:
This project was sponsored by the Key Project of National Defense Basic Research (No. B3720132001), the National Natural Scientific Foundation of China (No. 81400117), China Postdoctoral Science Foundation (No. 2014 M562115), Hunan Provincial Natural Science Foundation of China (No. 2015JJ4043), and the Research Initiation Funding of University of South China for the Returned Scholars from Abroad (No. 2014XQD46).
机构署名:
本校为第一且通讯机构
院系归属:
核资源工程学院
药学与生物科学学院
摘要:
Differentially expressed proteins in liver tissues of C57BL/6J mice receiving low-dose 137Cs radiation were examined by proteomics analysis. Compared with the control group, 80 proteins were differentially expressed in the irradiated group. Among the 40 randomly selected proteins used for peptide mass fingerprinting analysis and bioinformatics, 24 were meaningful. These proteins were related to antioxidant defense, amino acid metabolism, detoxification, anti-tumor development, amino acid transport, anti-peroxidation, and composition of respirat...

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