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The detoxification activities and mechanisms of microcystinase towards MC-LR

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成果类型:
期刊论文
作者:
Cai, Danping;Wei, Jia;Huang, Feiyu;Feng, Hai;Peng, Tangjian;...
通讯作者:
Fei Yang
作者机构:
[Cai, Danping] Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang, China. Electronic address: 20202014210994@stu.usc.edu.cn
[Wei, Jia] Xiangya School of Public Health, Central South University, Changsha, China. Electronic address: wjcindy@csu.edu.cn
[Huang, Feiyu] The First People's Hospital of Jingzhou, Jingzhou, China. Electronic address: huangfeiyu@csu.edu.cn
[Feng, Hai] Xiangya School of Public Health, Central South University, Changsha, China. Electronic address: Fenghai@csu.edu.cn
[Peng, Tangjian] Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang, China. Electronic address: pengtangjian@usc.edu.cn
通讯机构:
[Fei Yang] H
Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang, China<&wdkj&>Xiangya School of Public Health, Central South University, Changsha, China
语种:
英文
关键词:
Homology modeling;Microcystinase;Microcystins;Molecular docking;Protein phosphatase 2A
期刊:
Ecotoxicology and Environmental Safety
ISSN:
0147-6513
年:
2022
卷:
236
页码:
113436
基金类别:
This work was supported by the Hunan Province Excellent Youth Fund ( 2020JJ3053 ), the Hunan Province Key Research and Development Projects ( 2022SK2089, 2019SK2041 ), the Huxiang Youth Talent Program ( 2021RC3107 ), and the National Natural Science Foundation of China ( 81773393 ).
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
Microcystins (MCs) are the most common and toxic cyanotoxins that are hazardous to human health and ecosystems. Microcystinase is the enzyme in charge of the initial step in the biodegradation of MCs. The characterization, application conditions, and detoxification mechanisms of microcystinase from an indigenous bacterium Sphingopyxis sp. YF1 towards MC-LR were investigated in the current study. The microcystinase gene of strain YF1 was most similar to Sphingomonas sp. USTB-05 and contained a CAAX-family conversed abortive Infection (ABI) domai...

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