The outer membrane protein Tp92 of Treponema pallidum delays human neutrophil apoptosis via the ERK, PI3K/Akt, and NF-?B pathways

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Weiwei;Li, Sijia;Wang, Jianye;Yu, Maoying;Yang, Hongyu;...

通讯作者：

Xu, Man;Wu, YM

作者机构：

[Li, Weiwei; Wu, Yimou; Yu, Maoying; Liu, Zhaoping; Li, Sijia; He, Zhangping; Tang, Yuanyuan; Xu, Man; Liu, Jie; Xu, M; Guo, Ningyuan; Yang, Hongyu; Wang, Jianye; Wu, YM] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang, Peoples R China.

[Li, Weiwei; Xie, Dongde] Second Peoples Hosp Foshan, Dept Clin Lab, Foshan, Peoples R China.

[Wang, Jianye] Tianjin Med Univ, Sch Basic Med Sci, Dept Immunol, Key Lab Immune Microenvironm & Dis,Minist Educ, Tianjin, Peoples R China.

[Zheng, Kang] Hengyang Cent Hosp, Dept Clin Lab, Hengyang, Peoples R China.

通讯机构：

[Xu, M; Wu, YM ] U

Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang, Peoples R China.

语种：

英文

关键词：

Apoptosis;ERK MAPK;NF-κB signaling pathways;PI3K/Akt;Tp92;Treponema;hPMNs;virulence factor pallidum

期刊：

Molecular Microbiology

ISSN：

0950-382X

年：

2023

卷：

120

期：

页码：

684-701

DOI：

10.1111/mmi.15164

基金类别：

Hunan clinical medical technology innovation guidance project [2021SK50402, 2021SK51716]; National Natural Science Foundation of China [32370206, 82002182]; Natural Science Foundation of Hunan Province [2021JJ40479, 2023JJ50534]; Research Foundation of Hunan Provincial Health Commission [202201063177, 202211003920]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]; Research Foundation of Education Bureau of Hunan Province [21A0282, 22B0422]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Tp92 impedes the activation of procaspase‐3 via the ERK MAPK, PI3K/Akt, and NF‐κB signaling pathways, consequently suppressing caspase‐3 activity within hPMNs, and thereby preventing hPMNs apoptosis. These findings provide valuable insights into the molecular mechanisms underlying Treponema pallidum infection and suggest potential therapeutic targets for syphilis treatment. Abstract Syphilis is a persistent sexually transmitted disease caused by infiltration of the elusive pathogen Treponema pallidum. Despite the prevalence of human polymor...

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The outer membrane protein Tp92 of Treponema pallidum delays human neutrophil apoptosis via the ERK, PI3K/Akt, and NF-?B pathways

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