The outer membrane protein Tp92 of Treponema pallidum induces human mononuclear cell death and IL-8 secretion

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Luo, Xi;Zhang, Xiaohong;Gan, Lin;Zhou, Chenglong;Zhao, Tie;...

通讯作者：

Zhao, Feijun

作者机构：

[Yu, Jian; Zhao, Feijun; Liu, Shuangquan; Gan, Lin; Luo, Xi; Zhou, Chenglong; Zhao, Tie; Zhang, Xiaohong; Zeng, Tiebing; Xiao, Yongjian] Univ South China, Inst Pathogen Biol, Collaborat Innovat Ctr New Mol Drug Res, Hengyang, Peoples R China.

[Yu, Jian; Zhao, Feijun; Liu, Shuangquan; Gan, Lin; Luo, Xi; Zhou, Chenglong; Zhao, Tie; Zhang, Xiaohong; Zeng, Tiebing; Xiao, Yongjian] Univ South China, Key Lab Special Pathogen Prevent & Control Hunan, Collaborat Innovat Ctr New Mol Drug Res, Hengyang, Peoples R China.

[Zhang, Xiaohong] Univ South China, Sch Med, Dept Histol & Embryol, Hengyang, Peoples R China.

[Liu, Shuangquan] Univ South China, Dept Clin Lab, Affiliated Hosp 1, Hengyang, Peoples R China.

[Xiao, Yongjian] Univ South China, Dept Clin Lab, Affiliated Hosp 2, Hengyang, Peoples R China.

通讯机构：

[Zhao, Feijun] U

Univ South China, Inst Pathogen Biol, Hengyang, Hunan, Peoples R China.

Univ South China, Key Lab Special Pathogen Prevent & Control Hunan, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

apoptosis;CD14;IL-8;membrane protein;pyroptosis;TLR2;Tp92;Treponema pallidum

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2018

卷：

期：

页码：

6039-6054

DOI：

10.1111/jcmm.13879

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81373230, 81301470]; Hunan Provincial Education Department Innovation Platform Project [17k080]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control [2014-5]; Hunan Provincial Cooperative Innovation Center for Molecular Target New Drug Study [2015-8]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Treponema pallidum is the pathogen that causes syphilis, a sexually transmitted disease; however, the pathogenic mechanism of this organism remains unclear. Tp92 is the only T. pallidum outer membrane protein that has structural features similar to the outer membrane proteins of other Gram-negative bacteria, but the exact functions of this protein remain unknown. In the present study, we demonstrated that the recombinant Tp92 protein can induce human mononuclear cell death. Tp92 mediated the human monocytic cell line derived from an acute monic...

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The outer membrane protein Tp92 of Treponema pallidum induces human mononuclear cell death and IL-8 secretion

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