Involvement of miR-145 in the development of aortic dissection via inducing proliferation, migration, and apoptosis of vascular smooth muscle cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Wenhui;Huang, Cheng;Ding, Huanyu;Luo, Jianfang;Liu, Yuan;...

通讯作者：

Jiang, Zhisheng

作者机构：

[Huang, Wenhui; Jiang, Zhisheng] Univ South China, Hengyang Med Sch, Inst Cardiovasc Dis, Hengyang, Hunan, Peoples R China.

[Huang, Wenhui; Jiang, Zhisheng] Univ South China, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

[Huang, Wenhui; Liu, Yuan; Ding, Huanyu; Huang, Cheng; Luo, Jianfang] Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Vasc Ctr,Guangdong Prov Key Lab Coronary Heart Di, Dept Cardiol,Guangdong Prov Peoples Hosp, Guangzhou, Peoples R China.

[Fan, Ruixin; Xiao, Fei; Fan, Xiaoping] Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Dept Cardiovasc Surg,Guangdong Prov Peoples Hosp, Vasc Ctr,Guangdong Prov Key Lab South China Struc, Guangzhou, Peoples R China.

通讯机构：

[Jiang, Zhisheng] U

Univ South China, Hengyang Med Sch, Inst Cardiovasc Dis, Hengyang, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

aortic dissection;miR-145;proliferation;SMAD3;vascular smooth muscle cell

期刊：

Journal of Clinical Laboratory Analysis

ISSN：

0887-8013

年：

2020

卷：

期：

页码：

e23028-

DOI：

10.1002/jcla.23028

基金类别：

This work was financially supported by the National Natural Science Foundation of China (81300230), and High-level Hospital Construction Project (DFJH201807).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Aim: The current study aimed to examine miR-145's contribution to thoracic aortic dissection (AD) development by modulating the biological functions of vascular smooth muscle cells (VSMCs). Methods: The concentration of circulating miR-145 was determined in patients with AD and healthy controls using quantitative polymerase chain reaction (qPCR). Aortic specimens were obtained from both individuals with Stanford type A AD undergoing surgical treatment and deceased organ donors (serving as controls) whose causes of death were nonvascular disease...

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Involvement of miR-145 in the development of aortic dissection via inducing proliferation, migration, and apoptosis of vascular smooth muscle cells

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