We thank to the Central Research Laboratory of Hainan General Hospital Affiliated to the University of South China for the technical assistance. This work was partly supported by grants from the Key Science and Technology Project of Hainan Province (ZDYF2018151). Conflict of interest statement: The authors declare no potential conflicts of interest associated with this study. Author contributions: T.W. and G.Q.W. designed the study; T.W., Y.M.D., Q.F., T.L., J.C.Y., Z.Y.S., L.H., and G.Q.W. performed the functional experiments, statistical analyses, and interpreted the data; T.W. and G.Q.W. co-wrote the manuscript. All of the authors agreed with the results and conclusions.
