FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis

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成果类型：

期刊论文

作者：

Deng, Xiangping;Li, Zhongli;Xiong, Runde;Liu, Juan;Liu, Renbo;...

通讯作者：

Xie, Zhizhong;Tang, Guotao

作者机构：

[Li, Zhongli; Liu, Juan; Tang, Guotao; Peng, Junmei; Zheng, Xing; Deng, Xiangping; Xie, Zhizhong; Liu, Renbo; Lei, Xiaoyong; Xiong, Runde; Cao, Xuan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

[Chen, Yanming] Jiuzhitang Co Ltd, Changsha, Hunan, Peoples R China.

[Xie, ZZ; Tang, GT] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xie, ZZ; Tang, GT] U

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

FS-7;MGC-803;Anticancer;HIF-1 alpha;Glycolysis

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2019

卷：

109

页码：

1659-1669

DOI：

10.1016/j.biopha.2018.11.001

基金类别：

This work was financially supported by Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study ( 0223-0002-0002000-49 ) and Innovation platform Open Foundation of education department of Hunan province (contract grant numbers 16K079 , 17K082 ).

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

In this study, we investigated the anticancer effects of FS-7, a flavonoid salicylate derivative, in human gastric carcinoma MGC-803 cell line and studied its preliminary anticancer effects. FS-7 displayed greater in vitro cytotoxicity against MGC-803 cell line compared with 5-Fu and had a certain extent of selectivity to cancer cells. The flow cytometry analysis revealed that FS-7 induced apoptosis MGC-803 cells and mainly caused cells arrest in the G2/M phase in a concentration-dependent manner. Additionally, FS-7 inhibited the colony formation and cell migration in a concentration-dependent...

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FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis

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