Characterization of DNA Methylation Episignatures for Radon-Induced Lung Cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yan, Ziyan;Chen, Huixi;Liu, Yuhao;Zhou, Lin;Zhu, Jiaojiao;...

通讯作者：

Zhou, Ping-Kun;Gu, YQ

作者机构：

[Wang, Yilong; Zhu, Jiaojiao; Zhou, Lin; Yan, Ziyan; Gu, Yongqing; Liu, Yuhao; Zhou, Ping-Kun] Beijing Inst Radiat Med, Beijing 100850, Peoples R China.

[Chen, Huixi; Gu, Yongqing] Univ South China, Hengyang Med Coll, Hengyang 421001, Peoples R China.

[Hou, Yifan; Gu, Yongqing] Hebei Univ, Coll Life Sci, Baoding 071001, Peoples R China.

[Zhang, Xinyu; Gu, Yongqing] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

[Chen, Zhongmin] PLA Rocket Force Characterist Med Ctr, Beijing 100850, Peoples R China.

通讯机构：

[Zhou, PK; Gu, YQ ] B

Beijing Inst Radiat Med, Beijing 100850, Peoples R China.

Univ South China, Hengyang Med Coll, Hengyang 421001, Peoples R China.

Hebei Univ, Coll Life Sci, Baoding 071001, Peoples R China.

Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

DNA methylation;MassArray;RRBS;episignatures;lung cancer;radon

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2025

卷：

期：

DOI：

10.3390/ijms26146873

基金类别：

National Natural Science Foundation of China; [82273568]; [82073488]

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

Radon (Rn) exposure has a strong association with lung cancer risk and is influenced by epigenetic modifications. To investigate the characterization of DNA methylation (DNAm) episignatures for radon-induced lung cancer, we detected the specific changes in DNAm in blood and lung tissues using reduced representation bisulfite sequencing (RRBS). We identified the differentially methylated regions (DMRs) induced by radon exposure. The bioinformatics analysis of the DMR-mapped genes revealed that pathways in cancer were affected by radon exposure. ...

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Characterization of DNA Methylation Episignatures for Radon-Induced Lung Cancer

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