Identification of integrin beta 1 as a prognostic biomarker for human lung adenocarcinoma using 2D-LC-MS/MS combined with iTRAQ technology

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成果类型：

期刊论文

作者：

Zhang, Peng-Fei*;Zeng, Gu-Qing;Yi, Lun-Zhao;Liu, Jian-Ping;Wan, Xun-Xun;...

通讯作者：

Zhang, Peng-Fei

作者机构：

[Qu, Jia-Quan; Yi, Lun-Zhao; Li, Cui; Tang, Can-E; Xiao, Zhi-Qiang; Li, Jian-Huang; Chen, Yu; Wan, Xun-Xun; Zhang, Peng-Fei; Zeng, Gu-Qing; Hu, Rong; Ye, Xu; Chen, Zhu-Chu; Liu, Jian-Ping] Cent S Univ, Chinese Minist Hlth, Key Lab Canc Prote, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.

[Zeng, Gu-Qing] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[Yi, Lun-Zhao] Cent S Univ, Res Ctr Modernizat Chinese Herbal Med, Coll Chem & Chem Engn, Changsha 410008, Hunan, Peoples R China.

[Zhang, Peng-Fei] Cent S Univ, Chinese Minist Hlth, Key Lab Canc Prote, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Zhang, Peng-Fei] C

Cent S Univ, Chinese Minist Hlth, Key Lab Canc Prote, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Lung adenocarcinoma;Plasma membrane proteome;Tumor biomarker;iTRAQ

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2013

卷：

期：

页码：

341-349

DOI：

10.3892/or.2013.2477

基金类别：

Major New Drug Discovery Science and Technology of China [2012ZX09303013-006]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272609, 21105129, 81102046]

机构署名：

本校为其他机构

院系归属：

护理学院

摘要：

To discover novel lung adenocarcinoma (AdC) biomarkers, isobaric tags for relative and absolute quantitation (iTRAQ)-tagging combined with 2D-LC-MS/MS analysis was used to identify differentially expressed plasma membrane proteins in lung AdC and paired paraneoplastic normal lung tissues (PNLTs) adjacent to tumors. In this study, significant caveolin-1 downregulation and integrin β1 upregulation was observed in primary lung AdC vs. PNLT. As there has been no report on the association of integrin β1 with lung AdC, immunohistochemical staining ...

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Identification of integrin beta 1 as a prognostic biomarker for human lung adenocarcinoma using 2D-LC-MS/MS combined with iTRAQ technology

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