eRNAbase: a comprehensive database for decoding the regulatory eRNAs in human and mouse

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成果类型：

期刊论文

作者：

Song, Chao;Zhang, Guorui;Mu, Xinxin;Feng, Chenchen;Zhang, Qinyi;...

通讯作者：

Tang, Huifang;Li, CQ;Tang, HF

作者机构：

[Zhang, Yuexin; Mu, Xinxin; Zhang, Qinyi; Li, Chunquan; Song, Shuang; Zhang, Guorui; Song, Chao; Tang, Huifang; Yin, Mingxue; Zhang, Hang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuexin; Mu, Xinxin; Zhang, Qinyi; Li, Chunquan; Song, Shuang; Zhang, Guorui; Song, Chao; Tang, Huifang; Yin, Mingxue; Zhang, Hang] Univ South China, Hengyang Med Sch, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Qinyi; Li, Chunquan; Song, Shuang; Zhang, Guorui; Yin, Mingxue] Univ South China, Sch Basic Med Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Qinyi; Li, Chunquan; Song, Shuang; Zhang, Guorui; Yin, Mingxue] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

[Li, Chunquan] Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, CQ ; Tang, HF ; Tang, HF] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Basic Med Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

gated blood-pool imaging;chromatin;genetics;mice;enhancer of transcription;candidate disease gene;single nucleotide polymorphism;crispr;genes;rna;genome;methylation

期刊：

Nucleic Acids Research

ISSN：

0305-1048

年：

2024

卷：

期：

页码：

D81-D91

DOI：

10.1093/nar/gkad925

基金类别：

National Natural Science Foundation of China [62171166, 62001145, 62302206]; Research Foundation of the First Affiliated Hospital of University of South China for Advanced Talents [20210002-1005 USCAT-2021-01]; China Postdoctoral Science Foundation [2019M661311]; Natural Science Foundation of Hunan Province [2023JJ30547, 2023JJ40594, 2023JJ30536]; Scientific Research Fund Project of Hunan Provincial Health Commission [20201920]; Special Funds for the Construction of Innovative Provinces in Hunan [2020SK4008]; Key Project of Hunan Provincial Science and Technology Innovation [No. 2020SK1013-2]; Clinical Research 4310 Program of the University of South China [20214310NHYCG03]. Funding for open access charge: Research Foundation of the First Affiliated Hospital of University of South China.

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

Enhancer RNAs (eRNAs) transcribed from distal active enhancers serve as key regulators in gene transcriptional regulation. The accumulation of eRNAs from multiple sequencing assays has led to an urgent need to comprehensively collect and process these data to illustrate the regulatory landscape of eRNAs. To address this need, we developed the eRNAbase (http://bio.liclab.net/eRNAbase/index.php) to store the massive available resources of human and mouse eRNAs and provide comprehensive annotation and analyses for eRNAs. The current version of eRNAbase cataloged 10 399 928 eRNAs from 1012 samples...

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eRNAbase: a comprehensive database for decoding the regulatory eRNAs in human and mouse

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