Twist is an important member of highly conservative basic helix-ring-spiral transcription factor family,and plays an essential role in embryogenesis,cell motility and tissue shaping.Recent studies have shown that Twist is an oncogene closely related to many tumors,and plays a crucial role in tumorigenesis,invasion and metastasi of osteosarcoma,which is the most common primary malignancy of bone,and has high grade of malignancy and poor prognosis that its standard treatment was surgical amputation.With the development of non-surgical treatment such as neoadjuvant chemotherapy and genetic target...
