α-1 Antitrypsin is a potential target of inflammation and immunomodulation (Review)

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Tiantian;Shuai, Peimeng;Wang, Qingyu;Guo, Caimao;Huang, Shuqi;...

通讯作者：

Yi, L

作者机构：

[Shuai, Peimeng; Yi, L; Li, Yuanyuan; Yi, Lan; Huang, Shuqi; Wang, Tiantian] Univ South China, Inst Cytol & Genet, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hengyang Key Lab Cellular Stress, 28 Changsheng West Rd,Hongxiang St, Hengyang 421001, Hunan, Peoples R China.

[Yi, Lan; Guo, Caimao; Wu, Wenyu; Wang, Qingyu] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hengyang Key Lab Cellular Stress, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yi, L ] U

Univ South China, Inst Cytol & Genet, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hengyang Key Lab Cellular Stress, 28 Changsheng West Rd,Hongxiang St, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

autoimmune disease;immune‑mediated inflammation;immunomodulator;serine protease inhibitor;α‑l antitrypsin

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2025

卷：

期：

DOI：

10.3892/mmr.2025.13472

基金类别：

Hunan Natural Science Foundation

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

α‑1 Antitrypsin (AAT) is an acute phase protein encoded by the serine protease inhibitor family A member 1 gene. This multifunctional protein serves several roles, including anti‑inflammatory, antibacterial, antiapoptotic and immune regulatory functions. The primary role of AAT is to protect tissues and organs from protease‑induced damage due to its function as a serine protease inhibitor. AAT is associated with the development of lung inflammation, liver inflammation and immune‑mediated inflammatory diseases, which are influenced by envir...

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