Transforming growth factor 1 promotes migration and invasion in HepG2 cells: Epithelial-to-mesenchymal transition via JAK/STAT3 signaling

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成果类型：

期刊论文

作者：

Lin, Xiao-Long*;Liu, Mihua;Liu, Yuanbo;Hu, Huijun;Pan, Yongquan;...

通讯作者：

Lin, Xiao-Long

作者机构：

[Hu, Huijun; Fan, Xiaojuan; Pan, Yongquan; Lin, Xiao-Long; Zou, Weiwen; Hu, Xuemei] Guangzhou Med Univ, Huizhou Peoples Hosp 3, Dept Pathol, 1 Xuebei St, Huizhou 516002, Guangdong, Peoples R China.

[Liu, Mihua] Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China.

[Liu, Yuanbo] Sixth Peoples Hosp Huizhou, Dept Neurol, Huizhou 516211, Guangdong, Peoples R China.

通讯机构：

[Lin, Xiao-Long] G

Guangzhou Med Univ, Huizhou Peoples Hosp 3, Dept Pathol, 1 Xuebei St, Huizhou 516002, Guangdong, Peoples R China.

语种：

英文

关键词：

epithelial-to-mesenchymal transition;transforming growth factor 1;signal transducer and activator of transcription 3

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2018

卷：

期：

页码：

129-136

DOI：

10.3892/ijmm.2017.3228

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81600342]; Medical Foundation of Hui Zhou [2015Y134]; Medical Research Foundation of Guangdong Province [A2015620]; Graduate Student Research Innovation Project of Hunan Province [CX2013B396]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Transforming growth factor beta1 (TGFbeta1) is a cytokine with multiple functions. TGFbeta1 significantly induces migration and invasion of liver cancer cells. However, the molecular mechanisms underlying this effect remain unclear. Epithelialtomesenchymal transition (EMT) is crucial for the development of invasion and metastasis in human cancers. The aim of the present study was to determine whether TGFbeta1induced EMT promoted migration and invasion in HepG2 cells. The underlying mechanism and the effect of EMT on HepG2 cells were also investigated. The results demonstrated that TGFbeta1 may...

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Transforming growth factor 1 promotes migration and invasion in HepG2 cells: Epithelial-to-mesenchymal transition via JAK/STAT3 signaling

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