Extracellular vesicles of Bacteroides fragilis regulated macrophage polarization through promoted Sema7a expression

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成果类型：

期刊论文

作者：

Chen, Cong;He, Yu-Qi;Gao, Yan;Pan, Qun-Wen;Cao, Jing-Song

通讯作者：

Cao, JS

作者机构：

[Chen, Cong; He, Yu-Qi] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Lab Med, Hengyang 421001, Hunan, Peoples R China.

[Gao, Yan; Cao, Jing-Song] Univ South China, Affiliated Hosp 1, Inst Endocrinol & Metab, Ctr Clin Res Diabet,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Pan, Qun-Wen] Guangdong Med Univ, Inst Neurol, Guangdong Key Lab Age Related Cardiac & Cerebral D, Affiliated Hosp, Zhanjiang 524001, Peoples R China.

[Cao, Jing-Song] Univ South China, Inst Endocrinol & Metab, Dept Lab Med, Affiliated Hosp 1, Hengyang 421000, Hunan, Peoples R China.

通讯机构：

[Cao, JS ] U

Univ South China, Inst Endocrinol & Metab, Dept Lab Med, Affiliated Hosp 1, Hengyang 421000, Hunan, Peoples R China.

语种：

英文

关键词：

Bacteroides fragilis;Extracellular vesicles;Macrophage;Type 2 diabetes

期刊：

Microbial Pathogenesis

ISSN：

0882-4010

年：

2024

卷：

187

页码：

106527

DOI：

10.1016/j.micpath.2023.106527

基金类别：

This work was supported by The Research Foundation of Education Bureau of Hunan Province, China (No. 22A0292); Natural Science Foundation of Hunan Province, China (No. 2021JJ40490 and No. 2021JJ70113). CRediT authorship contribution statement Cong Chen: Writing – original draft, acquisition, Data curation. Yu-Qi He: Investigation. Yan Gao: Investigation. Qun-Wen Pan: Investigation. Jing-Song Cao: Writing – review & editing, acquisition, Data curation.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Abnormal activation of macrophage and gut Bacteroides fragilis (BF) are the important induction factors in the occurrence of type 2 diabetes (T2D) and vascular complications. However, it remains unknown whether BF involves in macrophage polarization. In this study, we found that BF extracellular vesicles (EV) can be uptaken by macrophage. BF-EV promote macrophage M1/M2 polarization significantly, and increase Sting expression significantly. Bioinformatics analysis found that Sema7a is an important gene involving in macrophage polarization. The expression of Sema7a can be induced by BF-EV and c...

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Extracellular vesicles of Bacteroides fragilis regulated macrophage polarization through promoted Sema7a expression

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