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Extracellular vesicles in atherosclerosis

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成果类型:
期刊论文
作者:
Deng, WenYi;Tang, TingTing;Hou, YangFeng;Zeng, Qian;Wang, YuFei;...
通讯作者:
Fan, WenJing;Qu, ShunLin
作者机构:
[Wang, YuFei; Fan, WenJing; Qu, ShunLin; Deng, WenYi; Tang, TingTing; Zeng, Qian] Univ South China, Hunan Int Sci & Technol Cooperat Base Arterioscle, Inst Cardiovasc Dis, Pathophysiol Dept,Key Lab Arteriosclerol Hunan Pr, 28 West Chang Sheng Rd, Hengyang City 421001, Hunan, Peoples R China.
[Fan, WenJing] Univ South China, Affiliated Hosp 2, Emergency Dept, Hengyang City 421001, Hunan, Peoples R China.
[Hou, YangFeng] Univ South China, Hengyang Med Sch, Med Clin Dept, Hengyang City 421001, Hunan, Peoples R China.
通讯机构:
[Fan, WJ; Qu, SL] U
Univ South China, Hunan Int Sci & Technol Cooperat Base Arterioscle, Inst Cardiovasc Dis, Pathophysiol Dept,Key Lab Arteriosclerol Hunan Pr, 28 West Chang Sheng Rd, Hengyang City 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Atherosclerosis;Cardiovascular diseases;Exosomes;Extracellular vesicles;Microvesicles
期刊:
Clinica Chimica Acta
ISSN:
0009-8981
年:
2019
卷:
495
页码:
109-117
基金类别:
We thank our colleagues in Professor Qu's group for technical assistance and stimulating discussions during the review. The authors declare that they have no competing interests. All the authors agree to publication of this review. This work was supported by grants from the National Natural Science Foundation of China (81670424), the Key Scientific Research Fund of Hunan Provincial Education Department (15A166), the Scientific Research Fund of Hunan Provincial Health and Family Planning Commission (B2016087 and B20180058), the National Natural Science Foundation of Hunan Province (2015JJ2118, 2019JJ40528 and 2019JJ50502), the Scientific Research Fund of Security Bureau of China (hunna-0013-2016AQ) and the project of “Research Study and Innovative Experiment Program for College Students” in University of South China (2017XJXZ031, 2017XJYZ048 and 2018XJXZ375).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Extracellular vesicles (EVs), which exist in human blood, are increased in some inflammation-related cardiovascular diseases. EVs are involved in inflammation, immunity, signal transduction, cell survival and apoptosis, angiogenesis, thrombosis, and autophagy, all of which are highly significant for maintaining homeostasis and disease progression. Therefore, EVs are also associated with key steps in atherosclerosis, including cellular lipid metabolism, endothelial dysfunction and vascular wall inflammation, ultimately resulting in vascular remodelling. In this review, we summarize recent studi...

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