版权说明 操作指南
首页 > 成果 > 详情

Prodigiosin inhibits proliferation and induces apoptosis through influencing amino acid metabolism in multiple myeloma

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
"Wang, Bingjie;Shi, Rui;Du, Wanqing;Guo, Jiaojiao;He, Nihan;...
通讯作者:
Feng, Xiangling
作者机构:
[Lu, Hongyu; Li, Xingli; Yu, Han; Shi, Rui; Du, Wanqing; "Wang, Bingjie; Zhong, Liyuan] Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Furong Laboratory, Xiangya School of Public Health, Central South University, 172# Tongzipo Road, Changsha, Hunan 410013, China
[Guo, Jiaojiao] Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
[Zhou, Wen; Zhu, Yinghong; He, Nihan] Cancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China
[Yang, Fei] School of Public Health, University of South China, Hengyang, Hunan 421001, China
[Yang, Fei] Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan 410013, China
通讯机构:
[Feng, Xiangling] H
Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Furong Laboratory, Xiangya School of Public Health, Central South University, 172# Tongzipo Road, Changsha, Hunan 410013, China. Electronic address:
语种:
英文
关键词:
ARSs;Amino acid metabolism;Multiple myeloma;Prodigiosin
期刊:
Bioorganic Chemistry
ISSN:
0045-2068
年:
2025
卷:
159
页码:
108349
基金类别:
CRediT authorship contribution statement Bingjie Wang: Writing – original draft, Investigation. Rui Shi: Writing – original draft, Data curation. Wanqing Du: Investigation, Formal analysis. Jiaojiao Guo: Supervision, Investigation. Nihan He: Validation, Investigation. Yinghong Zhu: Visualization. HanYu: Validation. Hongyu Lu: Validation, Software. Liyuan Zhong: Formal analysis. Xingli Li: Visualization. Wen Zhou: Supervision, Resources. Fei Yang: Methodology. Xiangling Feng: Writing – review & editing, acquisition.
机构署名:
本校为其他机构
院系归属:
公共卫生学院
摘要:
The recurrence of drug-resistant and expensive treatment drugs are major causes of the low survival rate of multiple myeloma (MM) patients. Exploring a safe, effective, low-cost and novel drug treatment for MM is a promising strategy to relieve the burden of MM patients. In this study, we found that prodigiosin could inhibit MM cell proliferation and induce MM cell apoptosis, however, it had a lesser cytotoxic effect on normal B cells within the IC 50 range of MM cells. In addition, prodigiosin could inhibit the growth of xenograft MM cells in mice. Transcriptomics and targeted amino acid meta...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com