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Prodigiosin inhibits prolifiration and induces apoptosis through influencing amino acid metabolism in multiple myeloma

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成果类型:
期刊论文
作者:
Bingjie Wang;Rui Shi;Wanqing Du;Jiaojiao Guo;Nihan He;...
通讯作者:
Xiangling Feng
作者机构:
[Bingjie Wang; Rui Shi; Wanqing Du; HanYu; Hongyu Lu; Liyuan Zhong; Xingli Li; Xiangling Feng] Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Furong Laboratory, Xiangya School of Public Health, Central South University, 172# Tongzipo Road, Changsha, Hunan 410013, China
[Nihan He; Yinghong Zhu; Wen Zhou] Cancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China
[Jiaojiao Guo] Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
School of Public Health, University of South China, Hengyang, Hunan 421001, China
Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan 410013, China
通讯机构:
[Xiangling Feng] H
Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Furong Laboratory, Xiangya School of Public Health, Central South University, 172# Tongzipo Road, Changsha, Hunan 410013, China
语种:
英文
期刊:
Bioorganic Chemistry
ISSN:
0045-2068
年:
2025
页码:
108349
基金类别:
CRediT authorship contribution statement Bingjie Wang: Writing – original draft, Investigation. Rui Shi: Writing – original draft, Data curation. Wanqing Du: Investigation, Formal analysis. Jiaojiao Guo: Supervision, Investigation. Nihan He: Validation, Investigation. Yinghong Zhu: Visualization. HanYu: Validation. Hongyu Lu: Validation, Software. Liyuan Zhong: Formal analysis. Xingli Li: Visualization. Wen Zhou: Supervision, Resources. Fei Yang: Methodology. Xiangling Feng: Writing – review & editing, acquisition.
机构署名:
本校为其他机构
院系归属:
公共卫生学院
摘要:
Recurrence of drug-resistant and expensive treatment drugs are major causes of the low survival rate of the multiple myeloma (MM) patients. Exploring a safe, effective, low-cost and novel drug treating MM is a promising strategy to relieve the burden of MM patients. In this study, we found that prodigiosin could inhibit MM cells proliferation and induce MM cell apoptosis, however, it had a lesser cytotoxic effect on normal B cells within the IC50 range of MM cells. In addition, prodigiosin could inhibit the growth of xenograft MM cells in mouse. Transcriptomics and targeted amino acid metabolo...

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