Temporally and spatially resolved molecular profiling in fingerprint analysis using indium vanadate nanosheets-assisted laser desorption ionization mass spectrometry

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhu, Yanli;Wang, Jikai;Fu, Chengxiao;Liu, Shuangquan;Awasthi, Pragati;...

通讯作者：

Wang, JK

作者机构：

[Zhu, Yanli] Hunan Univ Technol & Business, Sch Resources & Environm, Changsha 410205, Hunan, Peoples R China.

[Wang, Jikai; Mo, Ziyi; Wang, JK; Sun, Yiyang; Zeng, Pengfei] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Liu, Shuangquan; Chen, Danjun; Fu, Chengxiao] Univ South China, Affiliated Hosp 1, Hengyang Clin Pharmacol Res Ctr, Hengyang Med Sch,Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China.

[Awasthi, Pragati] Zhejiang Univ, State Key Lab Silicon Mat, Hangzhou 310058, Zhejiang, Peoples R China.

[Zeng, Pengfei] Zhejiang Univ, Sch Mat Sci & Engn, Hangzhou 310058, Zhejiang, Peoples R China.

通讯机构：

[Wang, JK ] U

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Indium vanadate nanosheets;Mass spectrometry imaging;Ionization mechanism;Chemical mapping;Fingerprint analysis

期刊：

Journal of Nanobiotechnology

ISSN：

1477-3155

年：

2023

卷：

期：

页码：

1-15

DOI：

10.1186/s12951-023-02239-w

基金类别：

This work is financially supported by the Natural Science Foundation of Hunan Province, China (2021JJ40452, 2021JJ80072, 2023JJ40220, 2023JJ60494), Scientific Research Project of Hunan Provincial Health Commission (202112062218), Scientific Research Project of Hunan Provincial Education Department (22B0455), Medical Technology Innovation Guidance Project of Hunan Province Science and Technology Department (2020SK51805), Macao Young Scholars Program (AM2022020), and Doctoral Scientific Research Foundation of University of South China (200XQD042).

机构署名：

本校为通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

This study presents the first-ever synthesis of samarium-doped indium vanadate nanosheets (IVONSs:Sm) via microemulsion-mediated solvothermal method. The nanosheets were subsequently utilized as a nano-matrix in laser desorption/ionization mass spectrometry (LDI-MS). It was discovered that the as-synthesized IVONSs:Sm possessed the following advantages: improved mass spectrometry signal, minimal matrix-related background, and exceptional stability in negative-ion mode. These qualities overcame the limitations of conventional matrices and enable...

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Temporally and spatially resolved molecular profiling in fingerprint analysis using indium vanadate nanosheets-assisted laser desorption ionization mass spectrometry

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