Long non-coding RNA PCA3 inhibits lipid accumulation and atherosclerosis through the miR-140-5p/RFX7/ABCA1 axis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Zhen-Wang;Zhang, Min;Liao, Ling-Xiao;Zou, Jin;Wang, Gang;...

通讯作者：

Yu, Xiao-Hua;Tang, Chao-Ke

作者机构：

[Qin, Yu-Sheng; Tang, Chao-Ke; Liao, Ling-Xiao; Zhao, Zhen-Wang; Zhou, Li; Li, Heng; Wang, Gang; Zou, Jin; Wan, Xiang-Jun; Zhang, Min] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, Hengyang Med Sch,Hunan Prov Cooperat Innovat Ctr, Hengyang 421001, Hunan, Peoples R China.

[Liao, Ling-Xiao] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Yu, Xiao-Hua] Hainan Med Univ, Inst Clin Med, Affiliated Hosp 2, Haikou 460106, Hainan, Peoples R China.

通讯机构：

[Yu, Xiao-Hua; Tang, Chao-Ke] I

Institute of Clinical Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 460106, China. Electronic address:

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic disease, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. Electronic address:

语种：

英文

关键词：

ABCA1;LncRNA PCA3;RFX7;atherosclerosis;miR-140-5p

期刊：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ISSN：

1388-1981

年：

2021

卷：

1866

期：

页码：

158904

DOI：

10.1016/j.bbalip.2021.158904

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770461]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ4548]

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

OBJECTIVE: The purpose of this study was to explore the role of long noncoding RNA (lncRNA) prostate cancer antigen 3 (PCA3) in atherosclerosis and the underlying mechanism. METHODS: The Gene Expression Omnibus (GEO) datasets were used to divide differentially expressed lncRNAs, microRNAs (miRNAs), and mRNAs. The expression of PCA3, miR-140-5p, RFX7 and ABCA1 were determined by qPCR or Western blot in ox-LDL-treated macrophages. Macrophage lipid accumulation s was evaluated using the Oil Red O staining and high-performance liquid chromatography. Target relationships among PCA3, miR-140-5p, RFX...

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Long non-coding RNA PCA3 inhibits lipid accumulation and atherosclerosis through the miR-140-5p/RFX7/ABCA1 axis

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