Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway

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成果类型：

期刊论文

作者：

Wu, Peng;Chen, JinNa;Chen, JiaoJiao;Tao, Jun;Wu, ShiYuan;...

通讯作者：

Wang, Zuo;Wei, DangHeng;Yin, WeiDong

作者机构：

[Chen, JinNa; Chen, JiaoJiao; Tao, Jun; Yin, WeiDong; Wei, DangHeng; Wu, Peng; Wang, Zuo] Univ South China, Hunan Int Sci & Technol Cooperat Base Arterioscle, Hunan Prov Innovat Training Base Med Postgrad, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang, Hunan, Peoples R China.

[Chen, JinNa; Chen, JiaoJiao; Tao, Jun; Yin, WeiDong; Wei, DangHeng; Wu, Peng; Wang, Zuo] Univ South China, Yueyang Woman & Childrens Med Ctr, Hengyang Med Coll, Hengyang, Hunan, Peoples R China.

[Xu, GaoSheng; Wu, ShiYuan; Wu, Peng] Hunan YueYang Maternal & Child Med Health Care Ho, Hunan Prov Innovat Training Base Med Postgrad, Yueyang, Hunan, Peoples R China.

[Wang, Zuo; Wei, DangHeng; Yin, WeiDong] Univ South China, Hengyang 42001, Hunan, Peoples R China.

通讯机构：

[Wang, Z; Wei, DH; Yin, WD] U

Univ South China, Hengyang 42001, Hunan, Peoples R China.

语种：

英文

关键词：

atherosclerosis;pyroptosis;ROS;SDHB;TMAO

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2020

卷：

235

期：

页码：

6582-6591

DOI：

10.1002/jcp.29518

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31870937, 81970389]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Trimethylamine N-oxide (TMAO) is produced from the phosphatidylcholine metabolism of gut flora and acts as a risk factor of cardiovascular disease. However, the underlying mechanisms for its proatherogenic action remain unclear. This study aimed to observe the effect of TMAO on endothelial cell pyroptosis and explore the underlying mechanisms. Our results showed that TMAO promoted the progression of atherosclerotic lesions in apolipoprotein E-deficient (apoE(-/-) ) mice fed a high-fat diet. Pyroptosis and succinate dehydrogenase complex subunit B (SDHB) upregulation were detected in the vascul...

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Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway

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