College of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, People's Republic of China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China<&wdkj&>College of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, People's Republic of China
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82073604, 21906077]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ5474, 2018JJ2323]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [20B508]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2021M690053]
机构署名：
本校为第一机构
院系归属：
公共卫生学院
摘要：
A label-free and selective sensor was established for uranyl ion (UO22+) detection based on a UO22+-dependent DNAzyme and liquid crystals (LCs). In the presence of UO22+, the substrate chains can be cleaved at the rA site by the DNAzyme strands. The cleaved products released from the DNAzyme strand will hybridize with the capture probes that are fixed on the LC sensing substrate to form double strands. The formation of double strands would disturb the original orientation and induce the rearrangement of liquid crystal molecules, resulting in th...
