Downregulation of Circular RNA circPSD3 Promotes Metastasis by Modulating FBXW7 Expression in Clear Cell Renal Cell Carcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xie, Xuexia;Li, Haomin;Gao, Chongqing;Lai, Yiqi;Liang, Junjie;...

通讯作者：

Lai, CY;Yao, N;Heng, BL

作者机构：

[Lai, Caiyong; Chen, Zheng; Li, Haomin; Xie, Xuexia] Jinan Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Peoples R China.

[Yao, Nan; Yao, N; Gao, Chongqing] Jinan Univ, Sch Med, Dept Pathophysiol, Guangzhou, Peoples R China.

[Lai, Yiqi] Univ South China, Hengyang, Peoples R China.

[Chen, Zhiwei; Liang, Junjie] Jinan Univ, Dept Hepatol Surg, Affiliated Hosp 1, Guangzhou, Peoples R China.

[Heng, Baoli; Heng, BL] Jinan Univ, Inst Kidney Surg, Yingde Ctr, Guangzhou, Guangdong, Peoples R China.

通讯机构：

[Lai, CY ; Yao, N ; Heng, BL ] J

Jinan Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Peoples R China.

Jinan Univ, Sch Med, Dept Pathophysiol, Guangzhou, Peoples R China.

Jinan Univ, Inst Kidney Surg, Yingde Ctr, Guangzhou, Guangdong, Peoples R China.

Peoples Hosp Yingde City, Dept Urol, Yingde, Peoples R China.

语种：

英文

期刊：

Journal of Oncology

ISSN：

1687-8450

年：

2022

卷：

2022

DOI：

10.1155/2022/5084631

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81903634, 81460386]; Science and Technology Project of Health Bureau of Yangjiang City [2021036]; Medical Scientific Research Foundation of Guangdong Province, China [A2019571, A2021091]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [21618303]; Flagship Specialty Construction Project-General Surgery of the First Affiliated Hospital of the Jinan University [711003]; Prof. Jian Hongs group at the Jinan University

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摘要：

Circular RNAs (circRNAs), a novel class of noncoding RNAs, have been shown to play critical regulatory roles in clear cell renal cell carcinoma (ccRCC). Metastasis is the main contributor to the poor prognosis of patients with ccRCC. However, the role of circRNAs in ccRCC metastasis has not been fully elucidated. In this study, microarray and RNA-seq analyses revealed that circPSD3 (hsa_circ_0002111) was dramatically downregulated in ccRCC tissues compared to adjacent nontumor tissues. A qRT-PCR analysis performed on our ccRCC cohorts confirmed...

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Downregulation of Circular RNA circPSD3 Promotes Metastasis by Modulating FBXW7 Expression in Clear Cell Renal Cell Carcinoma

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