期刊论文

中文

生理学报

0371-0874

2023

75

01

59-68

supported by the Natural Science Foundation of Hunan Province （No. 2018JJ2347, 2021JJ30595）； Hunan University Student Innovation and Entrepreneurship Project,China （No. S202010555125）；

本校为第一机构

本文旨在探究二氢杨梅素(dihydromyricetin,DHM)对2型糖尿病(type 2 diabetes mellitus,T2DM)大鼠帕金森病(Parkinson’s disease,PD)样病变的作用及机制。...展开更多 本文旨在探究二氢杨梅素(dihydromyricetin,DHM)对2型糖尿病(type 2 diabetes mellitus,T2DM)大鼠帕金森病(Parkinson’s disease,PD)样病变的作用及机制。喂养SpragueDawley(SD)大鼠高脂饲料和腹腔注射链脲佐菌素(streptozocin,STZ)建立T2DM模型,用DHM(每天125或250 mg/kg灌胃)处理24周,用平衡木实验检测大鼠运动能力,用免疫组织化学法检测大鼠中脑多巴胺能(dopaminergic,DA)神经元细胞变化和自噬启动相关蛋白ULK1的表达,用Wes...

The purpose of this study was to explore the effect and mechanism of dihydromyricetin(DHM)on Parkinson’s disease(PD)-like lesions in type 2 diabetes mellitus(T2DM)rats.The T2DM model was established by feeding Sprague Dawley(SD)rats with high-fat diet and intraperitonea...MORE The purpose of this study was to explore the effect and mechanism of dihydromyricetin(DHM)on Parkinson’s disease(PD)-like lesions in type 2 diabetes mellitus(T2DM)rats.The T2DM model was established by feeding Sprague Dawley(SD)rats with high-fat diet and intraperitonea...