SIGLEC15 SHAPES A NON-INFLAMED TUMOR MICROENVIRONMENT AND PREDICTS THE MOLECULAR SUBTYPE IN BLADDER CANCER

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Jiao;Yu, Anze;Othmane, Belaydi;Qiu, Dongxu;Li, Huihuang;...

通讯作者：

Chen, Jinbo;Zu, Xiongbing

作者机构：

[Li, Huihuang; Qiu, Dongxu; Liu, Peihua; Hu, Jiao; Zu, Xiongbing; Ren, Wenbiao; Yu, Anze; Chen, Jinbo; Othmane, Belaydi; Chen, Minfeng; Li, Chao] Cent South Univ, Xiangya Hosp, Dept Urol, Changsha 410008, Peoples R China.

[Yu, Anze] Texas Med Ctr, Houston Methodist Res Inst, Immunobiol & Transplant Sci Ctr, Houston, TX 77030 USA.

[Gong, Guanghui] Cent South Univ, Dept Pathol, Xiangya Hosp, Changsha, Peoples R China.

[Guo, Xi] Hunan Prov Peoples Hosp, Dept Urol, Changsha, Peoples R China.

[Zhang, Huihui] Univ South China, Dept Urol, Affiliated Hosp 1, Hengyang, Peoples R China.

通讯机构：

[Chen, JB; Zu, XB] C

Cent South Univ, Xiangya Hosp, Dept Urol, Changsha 410008, Peoples R China.

语种：

英文

关键词：

Siglec15;Bladder cancer;Immunotherapy;Molecular subtype;Tumor microenvironment

期刊：

THERANOSTICS

ISSN：

1838-7640

年：

2021

卷：

期：

页码：

3089-3108

DOI：

10.7150/thno.53649

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873626, 81902592]; Hunan Natural Science FoundationNatural Science Foundation of Hunan Province [2020JJ5884]; Hunan Province Key RD Program [2019SK2202]; Xiangya Hospital Youth Fund [2018Q09]

机构署名：

本校为其他机构

摘要：

Rationale: Siglec15 is an emerging target for normalization cancer immunotherapy. However, pan-cancer anti-Siglec15 treatment is not yet validated and the potential role of Siglec15 in bladder cancer (BLCA) remains elusive. Methods: We comprehensively evaluated the expression pattern and immunological role of Siglec15 using pan-cancer analysis based on RNA sequencing data obtained from The Cancer Genome Atlas. We then systematically correlated Siglec15 with immunological characteristics in the BLCA tumor microenvironment (TME), including immunomodulators, cancer immunity cycles, tumor-infiltra...

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SIGLEC15 SHAPES A NON-INFLAMED TUMOR MICROENVIRONMENT AND PREDICTS THE MOLECULAR SUBTYPE IN BLADDER CANCER

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