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Reposition of lenalidomide as a radiation protector based on LINCS gene expression signatures and its preclinical validation

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成果类型:
期刊论文
作者:
Huang, Qi;Yin, Xiaoyao;Guan, Hua;Huang, Xin;Huang, Bo;...
通讯作者:
Zhou, PK;Xie, Dafei
作者机构:
[Zhou, Pingkun; Huang, Qi; Huang, Bo] Univ South China, Sch Publ Hlth, Dept Prevent Med, Hengyang 421001, Hunan, Peoples R China.
[Yin, Xiaoyao] Natl Ctr Biomed Anal, Beijing 100039, Peoples R China.
[Huang, Xin; Zhou, Pingkun; Guan, Hua; Xie, Dafei; Xie, DF] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol BKLRB, Beijing 100850, Peoples R China.
通讯机构:
[Zhou, PK ] U
[Xie, DF] B
Univ South China, Sch Publ Hlth, Dept Prevent Med, Hengyang 421001, Hunan, Peoples R China.
Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol BKLRB, Beijing 100850, Peoples R China.
语种:
英文
关键词:
Drug reposition;Enrichment score;Immunoregulation;LINCS;Lenalidomide;Radioprotection
期刊:
Scientific Reports
ISSN:
2045-2322
年:
2025
卷:
15
期:
1
页码:
12955
基金类别:
The National Natural Science Foundation of China [7232107]; Beijing Natural Science Foundation [AMMS-QNTB- 2022 - 001]; Young Elite Program [32171238, 82230108]; National Natural Science Foundation of China
机构署名:
本校为第一且通讯机构
院系归属:
医学院
公共卫生学院
摘要:
Ionizing radiation induces DNA damage and impairs genomic integrity, leading to cell death and tissue injuries or carcinogenesis. Medical radiation protectors are essential and necessary. However, there are limited radioprotectors in clinics, which can't meet the growing demand for countering radiation emergencies. Traditional drug discovery approach has been proven expensive and risky. Computational drug repositioning provides an attractive strategy for radioprotector discovery. Here we constructed a systematic workflow to identify repositioni...

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