3-Methyladenine potentiates paclitaxel-induced apoptosis and phosphorylation of cyclin-dependent kinase 1 at thr161 in nasopharyngeal carcinoma cell

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成果类型：

期刊论文

作者：

Wu, Xiaoqi;He, Yechuan;Yuan, Yeqin;Tan, Xian;Zhu, Lin;...

通讯作者：

Jiang, BY

作者机构：

[Zhu, Lin; Tan, Xian; He, Yechuan; Wu, Xiaoqi; Wang, Danling] Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Zhu, Lin; Tan, Xian; He, Yechuan; Wu, Xiaoqi; Wang, Danling] Univ South China, Inst Future Sci, Changsha 410008, Peoples R China.

[Jiang, Binyuan] Univ South China, Affiliated Changsha Cent Hosp, Med Res Ctr, Hengyang Med Sch, Changsha 410004, Peoples R China.

[Jiang, Binyuan; Yuan, Yeqin; Wang, Danling] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Clin Lab, Changsha 410004, Peoples R China.

通讯机构：

[Jiang, BY ] U

Univ South China, Affiliated Changsha Cent Hosp, Med Res Ctr, Hengyang Med Sch, Changsha 410004, Peoples R China.

Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Clin Lab, Changsha 410004, Peoples R China.

语种：

英文

关键词：

Nasopharyngeal carcinoma;Paclitaxel;3-Methyladenine;Cell cycle;Apoptosis

期刊：

生物细胞(英文)

ISSN：

0327-9545

年：

2024

卷：

期：

页码：

861-872

DOI：

10.32604/biocell.2024.048758

基金类别：

Science and Technology Innovation Program of Hunan Province [2021SK1014, 2022WZ1027]; Colleges and Universities of Hunan Province [HNJG 2020 0440]; Scientific Research Fund of Hunan Provincial Education Department [21B0411]; Scientific Research Project of Changsha Central Hospital [YNKY202201]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: Nasopharyngeal carcinoma (NPC) exhibits a significant prevalence in the southern regions of China, and paclitaxel (PTX) is frequently employed as a medication for managing advanced NPC. However, drug resistance is typically accompanied by a poor prognosis. Exploring the synergistic potential of combining multiple chemotherapeutic agents may represent a promising avenue for optimizing treatment efficacy. Methods: This study investigated whether 3-Methyladenine (3 -MA) could potentiated the effect of PTX and its potential molecular mechanism. Samples were divided into the following c...

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3-Methyladenine potentiates paclitaxel-induced apoptosis and phosphorylation of cyclin-dependent kinase 1 at thr161 in nasopharyngeal carcinoma cell

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