Endothelin-1 Upregulates the Expression of High Mobility Group Box 1 in Human Bronchial Epithelial Cells

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成果类型：

期刊论文

作者：

Li, Jianmin;Guan, Jing;Long, Xiaoping;Xiang, Xudong*

通讯作者：

Xiang, Xudong

作者机构：

[Li, Jianmin] Hunan Prov Peoples Hosp, Dept Resp Med, Changsha, Hunan, Peoples R China.

[Guan, Jing] First Hosp Changsha City, Dept Emergency Med, Changsha, Hunan, Peoples R China.

[Long, Xiaoping] Univ South China, Dept Resp Med, Affiliated Hosp 1, Hengyang, Peoples R China.

[Xiang, Xudong] Cent S Univ, Dept Resp Med, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.

[Xiang, Xudong] Cent S Univ, Dept Resp Med, Xiangya Hosp 2, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Xiang, Xudong] C

Cent S Univ, Dept Resp Med, Xiangya Hosp 2, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

Endothelin-1;High mobility group box 1;Bronchial epithelial cells;Endothelin A receptor;Focal adhesion kinase;Acute lung injury;Acute respiratory distress syndrome

期刊：

PHARMACOLOGY

ISSN：

0031-7012

年：

2015

卷：

期：

3-4

页码：

144-150

DOI：

10.1159/000435888

基金类别：

Hunan Provincial Natural Science Foundation, PR China [14A1627]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Both endothelin-1 (ET-1) and high mobility group box 1 (HMGB1) reportedly are closely involved in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). In this study, we explored the regulatory effects of ET-1 on the expression of HMGB1 in human bronchial epithelial cells (HBEpCs). Primary HBEpCs were treated with ET-1 with or without transcription inhibitor actinomycin D, ETA receptor blocker BQ123, ETB receptor blocker BQ788, focal adhesion kinase (FAK) inhibitor or shRNA, or different kinase inhibitors. ET-1 increased the HMGB1 mRNA level in a statistically...

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Endothelin-1 Upregulates the Expression of High Mobility Group Box 1 in Human Bronchial Epithelial Cells

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