Immunization with Chlamydia psittaci plasmid-encoded protein CPSIT_p7 induces partial protective immunity against chlamydia lung infection in mice

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成果类型：

期刊论文

作者：

Tan, Yuan;Li, Yumeng;Zhang, Yang;Yu, Jian;Wen, Yating;...

通讯作者：

Wu, Yimou

作者机构：

[Yu, Jian; Lu, Chunxue; Wu, Yimou; Li, Yumeng; Tan, Yuan; Wen, Yating; Wang, Chuan; Xu, Man; Chen, Qian] Univ South China, Inst Pathogen Biol, Med Coll, Hengyang 421001, Peoples R China.

[Yu, Jian; Lu, Chunxue; Wu, Yimou; Li, Yumeng; Tan, Yuan; Wen, Yating; Wang, Chuan; Xu, Man; Chen, Qian] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Yu, Jian; Lu, Chunxue; Wu, Yimou; Li, Yumeng; Tan, Yuan; Wen, Yating; Wang, Chuan; Xu, Man; Chen, Qian] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

[Tan, Yuan] First Hosp Changsha City, Dermatol, Changsha 410000, Hunan, Peoples R China.

[Zhang, Yang] Univ South China, Dept Pathol, Hengyang 421001, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Inst Pathogen Biol, Med Coll, Hengyang 421001, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

*C. psittaci;*CD4+ T cells;*CPSIT_p7;*Plasmid protein;*Protective immunity

期刊：

Immunologic Research

ISSN：

0257-277X

年：

2018

卷：

期：

页码：

471-479

DOI：

10.1007/s12026-018-9018-3

基金类别：

This study was funded by the Natural Science Foundation of China (Grant No. 31270218, Grant No. 81171588, Grant No. 81671986) and the Special Foundation of Hunan Provincial Science and Technology Department (2013TT1003), the construct program of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (Grant No. 2014-5), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Grant No. 2015-351), and the Foundation of the First Hospital of Changsha City (Grant No. Y2018-18).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

The present study evaluated the immune-protective efficacy of the Chlamydia psittaci (C. psittaci) plasmid protein CPSIT_p7 and analyzed the potential mechanisms of this protection. The current study used recombinant CPSIT_p7 protein with Freund’s complete adjuvant and Freund’s incomplete adjuvant to vaccinate BALB/c mice. Adjuvants alone or PBS formulated with the same adjuvants was used as negative controls. Mice were intranasally challenged with 105 inclusion-forming units (IFU) of C. psittaci. We found that CPSIT_p7 vaccination significan...

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Immunization with Chlamydia psittaci plasmid-encoded protein CPSIT_p7 induces partial protective immunity against chlamydia lung infection in mice

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