期刊论文

Jiang, Z.-S.

英文

CURRENT MEDICINAL CHEMISTRY

0929-8673

2021

28

18

3666-3680

10.2174/0929867327999201116194634

This work has been supported by the National Natural Science Foundation of China (81670429, 81470435, 91839103 to ZS.Jiang), the International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province (2018WK4031), Sci-Tech projects of Changsha City, Hunan Province(KQ176026), and the “Double First-Class” project for innovative Group of Basic Medicine, University of South China (to ZS.Jiang).

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Atherosclerosis is a chronic arterial wall illness that forms atherosclerotic plaques within the arteries. Plaque formation and endothelial dysfunction are atherosclerosis' characteristics. It is believed that the occurrence and development of atherosclerosis mainly include endothelial cell damage, lipoprotein deposition, inflammation and fibrous cap formation, but its molecular mechanism has not been elucidated. Therefore, protecting the vascular endothelium from damage is one of the key factors against atherosclerosis. The factors and processes involved in vascular endothelial inj...