Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced endothelial cell damage and mitochondrial dysfunction

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Yuanqin;Wang, Yanxia;Zheng, Hongyu;Xu, Qian;Zhou, Kun;...

通讯作者：

Jiang, ZS;Zheng, H

作者机构：

[Wang, Yanxia; Zhou, Kun; Tang, Zhi-Han; Xu, Qian; Wei, Dang-Heng; Jiang, Zhisheng; Jiang, Miao; Jiang, ZS; Zheng, Hongyu; Liu, Huiting; Zhao, Yuanqin; Liu, Lu-Shan] Univ South China, Inst Cardiovasc Dis, Int Joint Lab Arteriosclerot Dis Res Hunan Prov, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Peoples R China.

[Wang, Yanxia] Soochow Univ, Affiliated Hosp 1, Dept Pathol, Suzhou 215006, Peoples R China.

[Xia, Yu] Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Peoples R China.

[Zheng, He] Univ South China, Cent Hosp Shaoyang City, Hengyang Med Sch, Dept Hepatobiliary Surg, 360 Baoqing Middle Rd,Hongqi St, Shaoyang 422000, Peoples R China.

[Zheng, He] Univ South China, Affiliated Shaoyang Hosp, Hengyang Med Sch, 360 Baoqing Middle Rd,Hongqi St, Shaoyang 422000, Peoples R China.

通讯机构：

[Jiang, ZS ; Zheng, H ] U

Univ South China, Inst Cardiovasc Dis, Int Joint Lab Arteriosclerot Dis Res Hunan Prov, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Peoples R China.

Univ South China, Cent Hosp Shaoyang City, Hengyang Med Sch, Dept Hepatobiliary Surg, 360 Baoqing Middle Rd,Hongqi St, Shaoyang 422000, Peoples R China.

Univ South China, Affiliated Shaoyang Hosp, Hengyang Med Sch, 360 Baoqing Middle Rd,Hongqi St, Shaoyang 422000, Peoples R China.

语种：

英文

关键词：

Endothelial cells;Hydrogen sulfide;Mitochondrial dysfunction;SIRT1;ox-HDL

期刊：

NITRIC OXIDE-BIOLOGY AND CHEMISTRY

ISSN：

1089-8603

年：

2024

卷：

152

页码：

78-89

DOI：

10.1016/j.niox.2024.09.006

基金类别：

National Key Research and Development Program of China [2019YFA0801601]; National Natural Science Foundation of China [9183910, 81670429]; Special Funding for Construction of Innovative Provinces in Hunan Province [2020SK2105]; International Joint Laboratory for Arteriosclerotic Dis-ease Research of Hunan Province [2018WK4031]; Double First-Class" project for innovative Group of Basic Medicine, University of South China; Scientific Research Fund of Hunan Provincial Education Department [20C1576]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

BACKGROUND: Under normal circumstances, high-density lipoprotein (HDL) is considered to have cardiovascular protective effects, but the impact of oxidized HDL (ox-HDL) on vascular endothelial function remains poorly understood. Mitochondrial function is closely related to endothelial function, and hydrogen sulfide (H₂S) is a gas with endothelial protective properties. The novel hydrogen sulfide donor AP39 can target mitochondria to release H₂S, but the combined effects of ox-HDL and AP39 on vascular endothelium are not well studied. METHODS: ...

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Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced endothelial cell damage and mitochondrial dysfunction

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