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Astragalin Retards Atherosclerosis by Promoting Cholesterol Efflux and Inhibiting the Inflammatory Response via Upregulating ABCA1 and ABCG1 Expression in Macrophages

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成果类型:
期刊论文
作者:
Zhao, Zhen-Wang;Zhang, Min;Wang, Gang;Zou, Jin;Gao, Jia-Hui;...
通讯作者:
Yu, Xiao-Hua PhD
作者机构:
[Tang, Chao-Ke; Zhao, Zhen-Wang; Zhou, Li; Wang, Gang; Zou, Jin; Gao, Jia-Hui; Wan, Xiang-Jun; Zhang, Min] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Expt Ctr,Hengyang Med Sch,Hunan Int Sci &, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang, Hunan, Peoples R China.
[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.
[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.
[Yu, Xiao-Hua] Hainan Med Univ, Inst Clin Med, Affiliated Hosp 2, Haikou 460106, Hainan, Peoples R China.
通讯机构:
[Yu, Xiao-Hua PhD] I
Institute of Clinical Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
语种:
英文
关键词:
2 chloro 5 nitrobenzanilide;ABC transporter A1;ABC transporter G1;astragalin;immunoglobulin enhancer binding protein;interleukin 1beta;interleukin 6;liver X receptor alpha;monocyte chemotactic protein 1;parthenolide;peroxisome proliferator activated receptor gamma;toll like receptor 4;tumor necrosis factor;ABC transporter A1;ABCA1 protein, human;ABCA1 protein, mouse;ABCG1 protein, human;ABCG1 protein, mouse;antiinflammatory agent;astragalin;autacoid;cholesterol;kaempferol derivative;animal cell;animal experiment;animal model;animal tissue;apolipoprotein E knockout mouse;Article;atherosclerosis;atherosclerotic plaque;controlled study;drug effect;drug mechanism;foam cell;lipid metabolism;macrophage;male;mediator release;mouse;nonhuman;protein expression;upregulation;animal;atherosclerosis;disease model;genetics;HEK293 cell line;human;metabolism;pathology;THP-1 cell line;Animals;Anti-Inflammatory Agents;Atherosclerosis;ATP Binding Cassette Transporter 1;ATP Binding Cassette Transporter, Subfamily G, Member 1;Cholesterol;Disease Models, Animal;Foam Cells;HEK293 Cells;Humans;Inflammation Mediators;Kaempferols;Macrophages;Male;Mice, Knockout, ApoE;Plaque, Atherosclerotic;THP-1 Cells;Up-Regulation
期刊:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
ISSN:
0160-2446
年:
2021
卷:
77
期:
2
页码:
217-227
基金类别:
The authors gratefully acknowledge the financial support of the National Natural Sciences Foundation of China (81770461).
机构署名:
本校为第一机构
院系归属:
医学院
药学与生物科学学院
摘要:
Lipid metabolism disorder and inflammatory response are considered to be the major causes of atherosclerogenesis. Astragalin, the most important functional component of flavonoid obtained from persimmon leaves, has the hypolipidemic effects. However, it is unknown, how astragalin protects against atherosclerosis. The aim of this study was to observe the effects of astragalin on cholesterol efflux and inflammatory response and to explore the underlying mechanisms. Our results showed that astragalin upregulated the expression of ATP-binding casse...

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